Research and Scholarly Activity

The Department of Biomedical Sciences provides ample opportunities for student and residents to participate with faculty in research and scholarly activities. We offer experiences that enable discovery and promote creativity. As a department, we are committed to pursuing inquiry, disseminating knowledge, and fostering critical thinking that encourages lifelong learning.

Research and Scholarly Activity, 2011-16

Biomedical Sciences Research Chart

Recent Publications

Salmonella Meningitis Associated with Monocyte Infiltration in Mice.
Bauler TJ, Starr T, Nagy TA, Sridhar S, Scott D, Winkler CW, Steele-Mortimer O, Detweiler CS, Peterson KE
Am J Pathol. 2017 Jan; 187:1:187-199
PMID: 27955815

"Ping-pong gaze" secondary to monoamine oxidase inhibitor overdose.
Attaway A, Sroujieh L, Mersfelder TL, Butler C, Ouellette D
J Pharmacol Pharmacother. 2016 Jan-Mar; 7:1:34-7
PMID: 27127395

GAD vaccine reduces insulin loss in recently diagnosed type 1 diabetes: findings from a Bayesian meta-analysis.
Beam CA, MacCallum C, Herold KC, Wherrett DK, Palmer J, Ludvigsson J, Type 1 Diabetes TrialNet Study Group.
Diabetologia. 2016 Oct 4
PMID: 27704166

Akt: A Therapeutic Target in Hepatic Ischemia-Reperfusion Injury.
Covington SM, Bauler LD, Toledo-Pereyra LH
J Invest Surg. 2016 Jul 27 :1-9
PMID: 27463073

Unraveling the immunopathogenesis of glomerular disease.
Dickinson BL
Clin Immunol. 2016 Aug; 169:89-97
PMID: 27373970

Rare Red Rashes: A Case Report of Levetiracetam-Induced Cutaneous Reaction and Review of the Literature.
Jones RT, Evans W, Mersfelder TL, Kavanaugh K
Am J Ther. 2016 May-Jun; 23:3:e944-6
PMID: 25259954

Mitochondrial H2O2 in Lung Antigen-Presenting Cells Blocks NF-κB Activation to Prevent Unwarranted Immune Activation.
Khare A, Raundhal M, Chakraborty K, Das S, Corey C, Kamga CK, Quesnelle K, St Croix C, Watkins SC, Morse C, Oriss TB, Huff R, Hannum R, Ray P, Shiva S, Ray A
Cell Rep. 2016 May 24; 15:8:1700-14
PMID: 27184852

Maternal depression is not just a problem early on.
Kothari C, Wiley J, Moe A, Liepman MR, Tareen RS, Curtis A
Public Health. 2016 Mar 10
PMID: 26972518

Intimate Partner Violence Associated with Postpartum Depression, Regardless of Socioeconomic Status.
Kothari CL, Liepman MR, Shama Tareen R, Florian P, Charoth RM, Haas SS, McKean JW, Moe A, Wiley J, Curtis A
Matern Child Health J. 2016 Jun; 20:6:1237-46
PMID: 26955998

Gabapentin: Abuse, Dependence, and Withdrawal.
Mersfelder TL, Nichols WH
Ann Pharmacother. 2016 Mar; 50:3:229-33
PMID: 26721643

Reply: Gabapentin: Abuse, Dependence, and Withdrawal.
Mersfelder TL, Nichols WH
Ann Pharmacother. 2016 Aug; 50:8:692
PMID: 27323794

A Case of Vivid Hallucinations Secondary to Ropinirole.
Motin S, Mersfelder TL, Hays B
Am J Ther. 2016 Mar 15
PMID: 26982100

A brief simulation intervention increasing basic science and clinical knowledge.
Sheakley ML, Gilbert GE, Leighton K, Hall M, Callender D, Pederson D
Med Educ Online. 2016; 21:30744
PMID: 27060102

A brief simulation intervention increasing basic science and clinical knowledge.
Sheakley ML, Gilbert GE, Leighton K, Hall M, Callender D, Pederson D
Med Educ Online. 2016 Jan; 21:1:30744
PMID: 28165950

Statistical considerations when analyzing biomarker data.
Beam CA
Clin Immunol. 2015 Nov; 161:1:31-6
PMID: 26111480

Use of Dried Capillary Blood Sampling for Islet Autoantibody Screening in Relatives: A Feasibility Study.
Bingley PJ, Rafkin LE, Matheson D, Steck AK, Yu L, Henderson C, Beam CA, Boulware DC, TrialNet Study Group
Diabetes Technol Ther. 2015 Dec; 17:12:867-71
PMID: 26375197

Heterogeneity in recent-onset type 1 diabetes - a clinical trial perspective.
Bollyky JB, Xu P, Butte AJ, Wilson DM, Beam CA, Greenbaum CJ, Type 1 Diabetes TrialNet Study Group
Diabetes Metab Res Rev. 2015 Sep; 31:6:588-94
PMID: 25689602

A novel whole-embryo culture model for pharmaceutical and developmental studies.
Calibuso-Salazar MJ, Ten Eyck GR
J Pharmacol Toxicol Methods. 2015 May-Jun; 73:21-6
PMID: 25724095

Help-seeking patterns among women experiencing intimate partner violence: do they forgo the criminal justice system if their adjudication wishes are not met?
Cerulli C, Kothari C, Dichter M, Marcus S, Kim TK, Wiley J, Rhodes KV
Violence Vict. 2015; 30:1:16-31
PMID: 25774412

β cell death and dysfunction during type 1 diabetes development in at-risk individuals.
Herold KC, Usmani-Brown S, Ghazi T, Lebastchi J, Beam CA, Bellin MD, Ledizet M, Sosenko JM, Krischer JP, Palmer JP, Type 1 Diabetes TrialNet Study Group
J Clin Invest. 2015 Mar 2; 125:3:1163-73
PMID: 25642774

Selectins in Liver Ischemia and Reperfusion Injury.
Jones RT, Toledo-Pereyra LH, Quesnelle KM
J Invest Surg. 2015; 28:5:292-300
PMID: 26374984

Optogenetic versus electrical stimulation of dopamine terminals in the nucleus accumbens reveals local modulation of presynaptic release.
Melchior JR, Ferris MJ, Stuber GD, Riddle DR, Jones SR
J Neurochem. 2015 Sep; 134:5:833-44
PMID: 26011081

Molecular responses to ischemia and reperfusion in the liver.
Quesnelle KM, Bystrom PV, Toledo-Pereyra LH
Arch Toxicol. 2015 May; 89:5:651-7
PMID: 25566829

State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization: A Scientific Statement From the American Heart Association.
Simons M, Alitalo K, Annex BH, Augustin HG, Beam C, Berk BC, Byzova T, Carmeliet P, Chilian W, Cooke JP, Davis GE, Eichmann A, Iruela-Arispe ML, Keshet E, Sinusas AJ, Ruhrberg C, Woo YJ, Dimmeler S, American Heart Association Council on Basic Cardiovascular Sciences and Council on Cardiovascular Surgery and Anesthesia
Circ Res. 2015 May 22; 116:11:e99-132
PMID: 25931450

The development and utility of a novel scale that quantifies the glycemic progression toward type 1 diabetes over 6 months.
Sosenko JM, Skyler JS, Beam CA, Boulware D, Mahon JL, Krischer JP, Greenbaum CJ, Rafkin LE, Matheson D, Herold KC, Palmer JP, Type 1 Diabetes TrialNet and Diabetes Prevention Trial–Type 1 Study Groups
Diabetes Care. 2015 May; 38:5:940-2
PMID: 25758770

A new approach for diagnosing type 1 diabetes in autoantibody-positive individuals based on prediction and natural history.
Sosenko JM, Skyler JS, DiMeglio LA, Beam CA, Krischer JP, Greenbaum CJ, Boulware D, Rafkin LE, Matheson D, Herold KC, Mahon J, Palmer JP, Type 1 Diabetes TrialNet Study Group, Diabetes Prevention Trial-Type 1 Study Group
Diabetes Care. 2015 Feb; 38:2:271-6
PMID: 25519451

Expression and localization of predicted inclusion membrane proteins in Chlamydia trachomatis.
Weber MM, Bauler LD, Lam J, Hackstadt T
Infect Immun. 2015 Dec; 83:12:4710-8
PMID: 26416906

Psychosis induced by zonisamide: a case report and review of the literature.
Abdoh M, Mersfelder TL, Melgar TA
Am J Ther. 2014 Jan-Feb; 21:1:e15-6
PMID: 22020087

Bullous pemphigoid associated with dipeptidyl peptidase IV inhibitors. A case report and review of literature.
Attaway A, Mersfelder TL, Vaishnav S, Baker JK
J Dermatol Case Rep. 2014 Mar 31; 8:1:24-8
PMID: 24748908

Virulent Francisella tularensis destabilize host mRNA to rapidly suppress inflammation.
Bauler TJ, Chase JC, Wehrly TD, Bosio CM
J Innate Immun. 2014; 6:6:793-805
PMID: 24902499

Recommendations for the definition of clinical responder in insulin preservation studies.
Beam CA, Gitelman SE, Palmer JP, Type 1 Diabetes TrialNet Study Group
Diabetes. 2014 Sep; 63:9:3120-7
PMID: 24722251

Victim Participation in Intimate Partner Violence Prosecution: Implications for Safety.
Cerulli C, Kothari CL, Dichter M, Marcus S, Wiley J, Rhodes KV
Violence Against Women. 2014 Jun 2; 20:5:539-560
PMID: 24894959

Insulin sensitizers in 2013: new insights for the development of novel therapeutic agents to treat metabolic diseases.
Colca JR, Tanis SP, McDonald WG, Kletzien RF
Expert Opin Investig Drugs. 2014 Jan; 23:1:1-7
PMID: 24073940

Mitochondrial ROS potentiates indirect activation of the AIM2 inflammasome.
Crane DD, Bauler TJ, Wehrly TD, Bosio CM
Front Microbiol. 2014; 5:438
PMID: 25191316

A systematic approach for the location of hand sanitizer dispensers in hospitals.
Cure L, Van Enk R, Tiong E
Health Care Manag Sci. 2014 Sep; 17:3:245-58
PMID: 24194381

Early-delayed, radiation-induced cognitive deficits in adult rats are heterogeneous and age-dependent.
Forbes ME, Paitsel M, Bourland JD, Riddle DR
Radiat Res. 2014 Jul; 182:1:60-71
PMID: 24937782

Exocyst complex protein expression in the human placenta.
Gonzalez IM, Ackerman WE 4th, Vandre DD, Robinson JM
Placenta. 2014 Jul; 35:7:442-9
PMID: 24856041

The peroxisomal proliferator-activated receptor (PPAR) α agonist, fenofibrate, prevents fractionated whole-brain irradiation-induced cognitive impairment.
Greene-Schloesser D, Payne V, Peiffer AM, Hsu FC, Riddle DR, Zhao W, Chan MD, Metheny-Barlow L, Robbins ME
Radiat Res. 2014 Jan; 181:1:33-44
PMID: 24397438

Cell fusion mediates dramatic alterations in the actin cytoskeleton, focal adhesions, and E-cadherin in trophoblastic cells.
Ishikawa A, Omata W, Ackerman WE 4th, Takeshita T, Vandré DD, Robinson JM
Cytoskeleton (Hoboken). 2014 Apr; 71:4:241-56
PMID: 24623684

Nitrite activates protein kinase A in normoxia to mediate mitochondrial fusion and tolerance to ischaemia/reperfusion.
Kamga Pride C, Mo L, Quesnelle K, Dagda RK, Murillo D, Geary L, Corey C, Portella R, Zharikov S, St Croix C, Maniar S, Chu CT, Khoo NK, Shiva S
Cardiovasc Res. 2014 Jan 1; 101:1:57-68
PMID: 24081164

Nitrite augments glucose uptake in adipocytes through the protein kinase A-dependent stimulation of mitochondrial fusion.
Khoo NK, Mo L, Zharikov S, Kamga-Pride C, Quesnelle K, Golin-Bisello F, Li L, Wang Y, Shiva S
Free Radic Biol Med. 2014 May; 70:45-53
PMID: 24556414

Does gender matter? Exploring mental health recovery court legal and health outcomes.
Kothari CL, Butkiewicz R, Williams ER, Jacobson C, Morse DS, Cerulli C
Health Justice. 2014 Dec 5; 2:1:12
PMID: 25530934

Improved birth weight for Black infants: outcomes of a Healthy Start program.
Kothari CL, Zielinski R, James A, Charoth RM, Sweezy Ldel C
Am J Public Health. 2014 Feb; 104 Suppl 1:S96-S104
PMID: 24354844

Inpatient hospitalization and intimate partner violence: who are we treating?
Kothari RU, Kothari C, DeBoer M, Koestner A, Rohs T
J Trauma Acute Care Surg. 2014 Jul; 77:1:129-36; discussion 136
PMID: 24977767

Blood vascular abnormalities in Rasa1(R780Q) knockin mice: implications for the pathogenesis of capillary malformation-arteriovenous malformation.
Lubeck BA, Lapinski PE, Bauler TJ, Oliver JA, Hughes ED, Saunders TL, King PD
Am J Pathol. 2014 Dec; 184:12:3163-9
PMID: 25283357

Redox control of indoleamine 2,3-dioxygenase expression and activity in human monocyte-derived dendritic cells is independent of changes in oxygen tension.
Mattox ML, D'Angelo JA, Dickinson BL
Scand J Immunol. 2014 May; 79:5:325-32
PMID: 24612287

Disease progression among 446 children with newly diagnosed type 1 diabetes located in Scandinavia, Europe, and North America during the last 27 yr.
Max Andersen ML, Nielsen LB, Svensson J, Pörksen S, Hougaard P, Beam C, Greenbaum C, Becker D, Petersen JS, Hansen L, Mortensen HB
Pediatr Diabetes. 2014 Aug; 15:5:345-54
PMID: 24731251

Food additive carrageenan: Part I: A critical review of carrageenan in vitro studies, potential pitfalls, and implications for human health and safety.
McKim JM
Crit Rev Toxicol. 2014 Mar; 44:3:211-43
PMID: 24456237

Reduction in CD4 central memory T-cell subset in costimulation modulator abatacept-treated patients with recent-onset type 1 diabetes is associated with slower C-peptide decline.
Orban T, Beam CA, Xu P, Moore K, Jiang Q, Deng J, Muller S, Gottlieb P, Spain L, Peakman M, Type 1 Diabetes TrialNet Abatacept Study Group
Diabetes. 2014 Oct; 63:10:3449-57
PMID: 24834977

Kidney: polycystic kidney disease.
Paul BM, Vanden Heuvel GB
Wiley Interdiscip Rev Dev Biol. 2014 Nov-Dec; 3:6:465-87
PMID: 25186187

Radiation-induced cognitive impairment and altered diffusion tensor imaging in a juvenile rat model of cranial radiotherapy.
Peiffer AM, Creer RM, Linville C, Olson J, Kulkarni P, Brown JA, Riddle DR, Robbins ME, Brunso-Bechtold JE
Int J Radiat Biol. 2014 Sep; 90:9:799-806
PMID: 24991879

ACC/AHA/AACVPR/AAFP/ANA concepts for clinician-patient shared accountability in performance measures: a report of the American College of Cardiology/American Heart Association Task Force on Performance Measures.
Peterson ED, Ho PM, Barton M, Beam C, Burgess LH, Casey DE Jr, Drozda JP Jr, Fonarow GC, Goff D Jr, Grady KL, King DE, King ML, Masoudi FA, Nielsen DR, Stanko S
Circulation. 2014 Nov 25; 130:22:1984-94
PMID: 25366994

ACC/AHA/AACVPR/AAFP/ANA concepts for clinician-patient shared accountability in performance measures: a report of the American College of Cardiology/American Heart Association Task Force on Performance Measures.
Peterson ED, Ho PM, Barton M, Beam C, Burgess LH, Casey DE Jr, Drozda JP Jr, Fonarow GC, Goff D Jr, Grady KL, King DE, King ML, Masoudi FA, Nielsen DR, Stanko S
J Am Coll Cardiol. 2014 Nov 18-25; 64:20:2133-45
PMID: 25439761

Use of the Diabetes Prevention Trial-Type 1 Risk Score (DPTRS) for improving the accuracy of the risk classification of type 1 diabetes.
Sosenko JM, Skyler JS, Mahon J, Krischer JP, Greenbaum CJ, Rafkin LE, Beam CA, Boulware DC, Matheson D, Cuthbertson D, Herold KC, Eisenbarth G, Palmer JP, Type 1 Diabetes TrialNet and Diabetes Prevention Trial-Type 1 Study Groups
Diabetes Care. 2014 Apr; 37:4:979-84
PMID: 24550217

Chronic fluoxetine treatment promotes submissive behavior in the territorial frog, Eleutherodactylus coqui.
Ten Eyck GR, Regen EM
Pharmacol Biochem Behav. 2014 Sep; 124:86-91
PMID: 24887449

Analysis of β-cell death in type 1 diabetes by droplet digital PCR.
Usmani-Brown S, Lebastchi J, Steck AK, Beam C, Herold KC, Ledizet M
Endocrinology. 2014 Sep; 155:9:3694-8
PMID: 25004096

Using GIS and secondary data to target diabetes-related public health efforts.
Curtis AB, Kothari C, Paul R, Connors E
Public Health Rep. 2013 May-Jun; 128:3:212-20
PMID: 23633736

What are barriers to nurses screening for intimate partner violence?
DeBoer MI, Kothari R, Kothari C, Koestner AL, Rohs T Jr
J Trauma Nurs. 2013 Jul-Sep; 20:3:155-60; quiz 161-2
PMID: 24005119

Systemic effects of fractionated, whole-brain irradiation in young adult and aging rats.
Forbes ME, Paitsel M, Bourland JD, Riddle DR
Radiat Res. 2013 Sep; 180:3:326-33
PMID: 23952575

Response to Comment on: Greenbaum et al. Fall in C-peptide during first 2 years from diagnosis: evidence of at least two distinct phases from composite type 1 diabetes TrialNet data. Diabetes 2012;61:2066-2073.
Greenbaum CJ, Beam CA, Type 1 Diabetes TrialNet Study Group
Diabetes. 2013 Jun; 62:6:e8
PMID: 23704535

Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase.
He Z, Zhu HH, Bauler TJ, Wang J, Ciaraldi T, Alderson N, Li S, Raquil MA, Ji K, Wang S, Shao J, Henry RR, King PD, Feng GS
Proc Natl Acad Sci U S A. 2013 Jan 2; 110:1:E79-88
PMID: 23236157

Reactivation of latent viruses in individuals receiving rituximab for new onset type 1 diabetes.
Kroll JL, Beam C, Li S, Viscidi R, Dighero B, Cho A, Boulware D, Pescovitz M, Weinberg A, Type 1 Diabetes TrialNet Anti CD-20 Study Group
J Clin Virol. 2013 Jun; 57:2:115-9
PMID: 23422292

Small-molecule intramimics of formin autoinhibition: a new strategy to target the cytoskeletal remodeling machinery in cancer cells.
Lash LL, Wallar BJ, Turner JD, Vroegop SM, Kilkuskie RE, Kitchen-Goosen SM, Xu HE, Alberts AS
Cancer Res. 2013 Nov 15; 73:22:6793-803
PMID: 24242070

A pre-matriculation learning program that enables medical students with low prerequisite scores to succeed.
Lindner I, Sacks D, Sheakley M, Seidel C, Wahlig BC, Rojas JD, Coleman MT
Med Teach. 2013 Oct; 35:10:872-3
PMID: 24050196

The impact of lecture attendance and other variables on how medical students evaluate faculty in a preclinical program.
Martin SI, Way DP, Verbeck N, Nagel R, Davis JA, Vandre DD
Acad Med. 2013 Jul; 88:7:972-7
PMID: 23702517

Trophoblast cell fusion and differentiation are mediated by both the protein kinase C and a pathways.
Omata W, Ackerman WE 4th, Vandre DD, Robinson JM
PLoS One. 2013; 8:11:e81003
PMID: 24236208

Inhibition of Notch pathway attenuates the progression of human immunodeficiency virus-associated nephropathy.
Sharma M, Magenheimer LK, Home T, Tamano KN, Singhal PC, Hyink DP, Klotman PE, Vanden Heuvel GB, Fields TA
Am J Physiol Renal Physiol. 2013 Apr 15; 304:8:F1127-36
PMID: 23389453

Proximal tubule proliferation is insufficient to induce rapid cyst formation after cilia disruption.
Sharma N, Malarkey EB, Berbari NF, O'Connor AK, Vanden Heuvel GB, Mrug M, Yoder BK
J Am Soc Nephrol. 2013 Feb; 24:3:456-64
PMID: 23411784

Acceleration of the loss of the first-phase insulin response during the progression to type 1 diabetes in diabetes prevention trial-type 1 participants.
Sosenko JM, Skyler JS, Beam CA, Krischer JP, Greenbaum CJ, Mahon J, Rafkin LE, Matheson D, Herold KC, Palmer JP, Type 1 Diabetes TrialNet and Diabetes Prevention Trial–Type 1 Study Groups
Diabetes. 2013 Dec; 62:12:4179-83
PMID: 23863814

The prediction of type 1 diabetes by multiple autoantibody levels and their incorporation into an autoantibody risk score in relatives of type 1 diabetic patients.
Sosenko JM, Skyler JS, Palmer JP, Krischer JP, Yu L, Mahon J, Beam CA, Boulware DC, Rafkin L, Schatz D, Eisenbarth G, Type 1 Diabetes TrialNet Study Group, Diabetes Prevention Trial-Type 1 Study Group
Diabetes Care. 2013 Sep; 36:9:2615-20
PMID: 23818528

c-Src activation mediates erlotinib resistance in head and neck cancer by stimulating c-Met.
Stabile LP, He G, Lui VW, Thomas S, Henry C, Gubish CT, Joyce S, Quesnelle KM, Siegfried JM, Grandis JR
Clin Cancer Res. 2013 Jan 15; 19:2:380-92
PMID: 23213056

Expression of flotillins in the human placenta: potential implications for placental transcytosis.
Walton JR, Frey HA, Vandre DD, Kwiek JJ, Ishikawa T, Takizawa T, Robinson JM, Ackerman WE 4th
Histochem Cell Biol. 2013 Mar; 139:3:487-500
PMID: 23064789

Cell number and neuropil alterations in subregions of the anterior hippocampus in a female monkey model of depression.
Willard SL, Riddle DR, Forbes ME, Shively CA
Biol Psychiatry. 2013 Dec 15; 74:12:890-7
PMID: 23607969