Research and Scholarly Activity

Orthopaedic Surgery Research and Scholarly Activity
Fifth-year resident Jessica Hart gives a presentation at the American Academy of Orthopaedic Surgeons 2017 Annual Meeting in San Diego, California.

The Department of Orthopaedic Surgery emphasizes both clinical and basic science research.  Many faculty have maintained an active role in scholarly pursuits and continue to provide ample opportunities for medical students and residents. Our department has partnered with many research programs within WMed. There is also a strong historical relationship with the School of Engineering at Western Michigan University. Many of the laboratories are housed within this school and have allowed for materials testing, orthopaedic implant design, and 3D printing.  More recently, our department has been charged to assist in the creation of a Masters of Science degree in Medical Engineering awarded by the medical school. The unique opportunity allows for entering Masters students to be immersed in all aspects of healthcare helping them to understand the complexities of patient care in order to create a quality improvement project or product. 

Each orthopaedic surgery resident is required to demonstrate scholarly activity and develop a thesis to be presented at one of our annual visiting professor events. Our residents are encouraged to submit their research work to local, regional, and national conferences. The Department of Orthopaedic Surgery supports these expenses by developing a Research and Educational Fund. Our department has also developed a Resident Research Committee that consists of orthopaedic faculty, biostatisticians, medical writers, and clinical research staff with the medical school to assist the resident in hypothesis driven research and study design. 

Thus, the Department of Orthopaedic Surgery is committed to pursuing inquiry, developing a culture of discovery, disseminating knowledge, and fostering critical and analytical thinking that encourages lifelong learning.

Research and Scholarly Activity, 2014-19Orthopaedic Surgery Research

Recent Publications

  • Chronic Pain A Practice of Anesthesia for Infants and Children. 2019:1063-1075.e2. doi: 10.1016/B978-0-323-42974-0.00045-8.

  • MicroRNA-200c incorporated 3D-printed tricalcium phosphate enhances bone regeneration Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium. 2019;40:332.

  • Enhancement of MicroRNA-200c on osteogenic differentiation and bone regeneration by targeting Sox2-Mediated Wnt Signaling and Klf4 Human Gene Therapy. 2019;30:1405-1418. doi: 10.1089/hum.2019.019.

  • MicroRNA-200c Attenuates Periodontitis by Modulating Proinflammatory and Osteoclastogenic Mediators Stem Cells and Development. 2019;28:1026-1036. doi: 10.1089/scd.2019.0027.

  • Early recognition of sepsis through emergency medical services pre-hospital screening American Journal of Emergency Medicine. 2019;37:1428-1432. doi: 10.1016/j.ajem.2018.10.036.

  • Juvenile Idiopathic Arthritis for the Pediatric Orthopedic Surgeon Orthopedic Clinics of North America. 2019;50:471-488. doi: 10.1016/j.ocl.2019.06.003.

  • Pedicle Screw Insertion: a Novel Approach to Enhance Anatomic Knowledge and Student Engagement Medical Science Educator. 2019;29:355-356. doi: 10.1007/s40670-019-00724-2.

  • Surgical Reconstruction Technique of Two Patients With Tarsal Type Preaxial Polydactyly: Two True Prehalluces Journal of Foot and Ankle Surgery. 2019;58:814-820. doi: 10.1053/j.jfas.2018.12.011.

  • Use of an Accelerated Discharge Pathway in Patients With Severe Cerebral Palsy Undergoing Posterior Spinal Fusion for Neuromuscular Scoliosis Spine Deformity. 2019;7:804-811. doi: 10.1016/j.jspd.2019.02.002.

  • Feasibility of Transosseous Nonarticular Fixation of Lisfranc Injuries Foot and Ankle International. 2019;40:672-678. doi: 10.1177/1071100719830947.

  • Perioperative Management of Foot and Ankle Surgical Patients Foot and Ankle Specialist. 2019;12:458-460. doi: 10.1177/1938640019880685.

  • Quantifying the Impact of Patient-Specific Factors and Disease Severity on Clinical Decision Making in Cuff Tear Arthropathy: A Case-Based Survey HSS Journal. 2019;15:276-285. doi: 10.1007/s11420-019-09695-x.

  • Setting Yourself Up for Success: Retrograde Intramedullary Nailing in Periprosthetic Fractures About Total Knee Arthroplasty Journal of orthopaedic trauma. 2019;33:S29-S32. doi: 10.1097/BOT.0000000000001567.

  • Clinical Characteristics and Long-term Outcomes After Septic Arthritis of the Native Glenohumeral Joint: A 20-year retrospective review Orthopedics. 2019;42:e118-e123. doi: 10.3928/01477447-20181227-01.

  • Osteochondral Allograft Transplantation in the Patellofemoral Joint: A Systematic Review American Journal of Sports Medicine. 2019;47:3009-3018. doi: 10.1177/0363546518814236.

  • Pain after anatomic total shoulder arthroplasty versus reverse total shoulder arthroplasty Orthopedics. 2019;42:E247-E252. doi: 10.3928/01477447-20190125-01.

  • Lower Extremity Surgical Treatment to Improve Function in a Patient with Gollop-Wolfgang Complex: A Case Report JBJS Case Connector. 2019;9 doi: 10.2106/JBJS.CC.18.00254.

  • Risk Factors for Prolonged Symptoms of Mild Traumatic Brain Injury: A Pediatric Sports Concussion Clinic Cohort Clinical Journal of Sport Medicine. 2019;29:11-17. doi: 10.1097/JSM.0000000000000494.

  • Orthopaedic surgery resident consultations at a level I trauma center Current Orthopaedic Practice. 2019;30:26-29. doi: 10.1097/BCO.0000000000000699.

  • Dall B., Eden S., Cho W., Karkenny A., Brooks D., Hayward G., Moldavsky M., Yandamuri S., Bucklen B. Biomechanical analysis of motion following sacroiliac joint fusion using lateral sacroiliac screws with or without lumbosacral instrumented fusion Clinical Biomechanics. 2019;68:182-189. doi: 10.1016/j.clinbiomech.2019.05.025.

  • Gustafson P., Gustafson P., Gustafson P., Veenstra J., Veenstra J., Veenstra J., Bearden C., Bearden C., Bearden C., Jastifer J., Jastifer J., Jastifer J. The Effect of Pitch Variation and Diameter Variation on Screw Pullout Foot and Ankle Specialist. 2019;12:258-263. doi: 10.1177/1938640018789999.

  • Jastifer J., McNitt A., Mack C., Kent R., McCullough K., Coughlin M., Anderson R. Synthetic Turf: History, Design, Maintenance, and Athlete Safety Sports Health. 2019;11:84-90. doi: 10.1177/1941738118793378.

  • Medda S., Snoap T., Carroll E. Treatment of Young Femoral Neck Fractures Journal of Orthopaedic Trauma. 2019;33:S1-S6. doi: 10.1097/BOT.0000000000001369.

  • Strontium-releasing fluorapatite glass-ceramic scaffolds: Structural characterization and in vivo performance Acta Biomaterialia. 2018;75:463-471. doi: 10.1016/j.actbio.2018.05.047.

  • A novel fixation technique for variant crescent fractures of the pelvis Current Orthopaedic Practice. 2018;29:534-536. doi: 10.1097/BCO.0000000000000688.

  • The General Orthopaedist: Going the Way of the Dinosaur or the Next Subspecialty?: AOA Critical Issues The Journal of bone and joint surgery. American volume. 2018;100:e96. doi: 10.2106/JBJS.17.01109.

  • Long-term outcomes of patients with diabetes mellitus undergoing percutaneous intervention for popliteal and infrapopliteal peripheral arterial disease Catheterization and Cardiovascular Interventions. 2018;92:117-123. doi: 10.1002/ccd.27571.

  • Alrafeek S., Alrafeek S., Jastifer J., Gustafson P. A stochastic finite element method for simulating trabecular bone ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE). 2018;3 doi: 10.1115/IMECE201887869.

  • Alrafeek S., Alrafeek S., Jastifer J., Jastifer J., Gustafson P., Gustafson P. A stochastic structural finite element model for trabecular bone and other structural foam 33rd Technical Conference of the American Society for Composites 2018. 2018;5:2927-2942.

  • Anderson R., Coughlin M., Coughlin M., Jastifer J., McCullough K. Letter Regarding: Performance and Return to Sport After Achilles Tendon Repair in National Football League Players Foot and Ankle International. 2018;39:130. doi: 10.1177/1071100717745265.

  • Elgafy H., Raberding C., Mooney M., Andrews K., Duggan J. Analysis of a ten step protocol to decrease postoperative spinal wound infections World Journal of Orthopaedics. 2018;9(11):271-284. doi: 10.5312/wjo.v9.i11.271.

  • Farias E., Lichterman M., Yuhas M., Thirkannad S. Interlocking K Wires Followed by Immediate Mobilization for Fractures of the Hand Techniques in Hand and Upper Extremity Surgery. 2018;22(1):3-9. doi: 10.1097/BTH.0000000000000175.

  • Jastifer J., Jastifer J., McCullough K. Fatigue Bending Strength of Jones Fracture Specific Screw Fixation Foot and Ankle International. 2018;39:493-499. doi: 10.1177/1071100717746121.

  • Kruppa C., Snoap T., Sietsema D., Schildhauer T., Dudda M., Jones C. Is the Midterm Progress of Pediatric and Adolescent Talus Fractures Stratified by Age? Journal of Foot and Ankle Surgery. 2018;57(3):471-477. doi: 10.1053/j.jfas.2017.10.031.

  • Matthias N., Hunt S., Wu J., Lo J., Smith Callahan L., Li Y., Huard J., Darabi R. Volumetric muscle loss injury repair using in situ fibrin gel cast seeded with muscle-derived stem cells (MDSCs) Stem Cell Research. 2018;27:65-73. doi: 10.1016/j.scr.2018.01.008.

  • Murray I., Robinson P., West C., Goudie E., Yong L., White T., LaPrade R. Reporting Standards in Clinical Studies Evaluating Bone Marrow Aspirate Concentrate: A Systematic Review Arthroscopy - Journal of Arthroscopic and Related Surgery. 2018;34(4):1366-1375. doi: 10.1016/j.arthro.2017.11.036.

  • Tang M., Bai X., Li Y., Dai X., Yang F. MMP-1 Over-expression Promotes Malignancy and Stem-Like Properties of Human Osteosarcoma MG-63 Cells In Vitro Current Medical Science. 2018;38(5):809-817. doi: 10.1007/s11596-018-1947-5.

  • Tanner B., Lu S., Zervoudakis G., Woodwyk A., Munene G. Coagulation profile following liver resection: Does liver cirrhosis affect thromboelastography? American Journal of Surgery. 2018;215(3):406-409. doi: 10.1016/j.amjsurg.2017.10.047.

  • Controlled and Sequential Delivery of Fluorophores from 3D Printed Alginate-PLGA Tubes Annals of Biomedical Engineering. 2017;45:297-305. doi: 10.1007/s10439-016-1648-9.

  • Case of Nonspinal Osteomyelitis Due to Bartonella and Review of the Literature Infectious Diseases in Clinical Practice. 2017;25:240-242. doi: 10.1097/IPC.0000000000000511.

  • Burnout in Orthopaedic Surgeons: A Challenge for Leaders, Learners, and Colleagues Journal of Bone and Joint Surgery - American Volume. 2017;99 doi: 10.2106/JBJS.16.01215.

  • Immediate and Delayed Passive Range of Motion after Total Shoulder Arthroplasty Did Not Differ for Function or Range of Motion at 1 Year Journal of Bone and Joint Surgery - American Volume. 2017;99:1393. doi: 10.2106/JBJS.17.00553.

  • Antegrade endosteal fibular strut augmentation for periprosthetic femoral fracture above stemmed total knee arthroplasty Current Orthopaedic Practice. 2017;28:104-107. doi: 10.1097/BCO.0000000000000445.

  • Calcaneus Fractures: A Possible Musculoskeletal Emergency Journal of Emergency Medicine. 2017;52:28-33. doi: 10.1016/j.jemermed.2016.07.085.

  • Open hip dislocation through the scrotum without osseous injury: A case report JBJS Case Connector. 2017;7:e2. doi: 10.2106/JBJS.CC.16.00100.

  • A prospective randomized controlled trial to identify the optimal postoperative pain management in shoulder arthroplasty: liposomal bupivacaine versus continuous interscalene catheter Journal of Shoulder and Elbow Surgery. 2017;26:1810-1817. doi: 10.1016/j.jse.2017.06.044.

  • All-inside ACL reconstruction: How does it compare to standard ACL reconstruction techniques? Journal of Orthopaedics. 2017;14:241-246. doi: 10.1016/j.jor.2017.03.002.

  • Alden A., Alden A., Geeslin A., King J., Gustafson P. A finite element model of a surgical knot ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE). 2017;3 doi: 10.1115/IMECE2017-72201.

  • Choi Y., Meng F., Cox C., Lally K., Huard J., Li Y. Regeneration and regrowth potentials of digit tips in amphibians and mammals International Journal of Cell Biology. 2017;2017 doi: 10.1155/2017/5312951.

  • Flint W., Macias D., Jastifer J., Doty J., Hirose C., Coughlin M. Plantar Plate Repair for Lesser Metatarsophalangeal Joint Instability Foot and Ankle International. 2017;38:234-242. doi: 10.1177/1071100716679110.

  • Jastifer J., Doty J., Claassen L. Current concepts in the treatment of metatarsophalangeal joint instability of the lesser toes: Review, surgical technique, and early outcomes Fuss und Sprunggelenk. 2017;15:225-236. doi: 10.1016/j.fuspru.2017.07.001.

  • Jastifer J., Green A. Gastrocnemius Contracture in Patients With Rheumatoid Arthritis Foot and Ankle International. 2017;38:1362-1366. doi: 10.1177/1071100717728860.

  • Jastifer J., Gustafson P. Three-Dimensional Printing and Surgical Simulation for Preoperative Planning of Deformity Correction in Foot and Ankle Surgery Journal of Foot and Ankle Surgery. 2017;56:191-195. doi: 10.1053/j.jfas.2016.01.052.

  • Jastifer J., Gustafson P., Labomascus A., Snoap T. Ball and Socket Ankle: Mechanism and Computational Evidence of Concept Journal of Foot and Ankle Surgery. 2017;56:773-775. doi: 10.1053/j.jfas.2017.02.019.

  • Jastifer J., Jaykel M. Results of the Gravity Stress Examination in the Normal Patient Population Foot and Ankle Specialist. 2017;10:398-401. doi: 10.1177/1938640016679702.

  • Jastifer J., Kent R., Kent R., Crandall J., Crandall J., Sherwood C., Lessley D., McCullough K., Coughlin M., Anderson R. The Athletic Shoe in Football: Apparel or Protective Equipment? Sports Health. 2017;9:126-131. doi: 10.1177/1941738117690717.

  • Li Y., Baldwin T., Wang Y., Subramaniam J., Carbajal A., Brand C., Cunha S., Dessauer C. Loss of type 9 adenylyl cyclase triggers reduced phosphorylation of Hsp20 and diastolic dysfunction Scientific Reports. 2017;7(1) doi: 10.1038/s41598-017-05816-w.

  • Liao G., Choi Y., Vojnits K., Xue H., Aroom K., Meng F., Pan H., Hetz R., Corkins C., Hughes T., Triolo F., Johnson A., Moise K., Lally K., Cox C., Li Y. Tissue Engineering to Repair Diaphragmatic Defect in a Rat Model Stem Cells International. 2017;2017 doi: 10.1155/2017/1764523.

  • Murray I., Gonzalez Z., Baily J., Dobie R., Wallace R., Mackinnon A., Smith J., Greenhalgh S., Thompson A., Conroy K., Griggs D., Ruminski P., Gray G., Singh M., Campbell M., Kendall T., Dai J., Li Y., Iredale J., Simpson H., Huard J., Péault B., Henderson N. αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis Nature Communications. 2017;8(1) doi: 10.1038/s41467-017-01097-z.

  • Vojnits K., Pan H., Dai X., Sun H., Tong Q., Darabi R., Huard J., Li Y. Functional Neuronal Differentiation of Injury-Induced Muscle-Derived Stem Cell-Like Cells with Therapeutic Implications Scientific Reports. 2017;7(1) doi: 10.1038/s41598-017-01311-4.

  • Orthopaedic considerations Health Care for People with Intellectual and Developmental Disabilities Across the Lifespan. 2016:1107-1122. doi: 10.1007/978-3-319-18096-0_94.

  • Principles of pharmacology Health Care for People with Intellectual and Developmental Disabilities Across the Lifespan. 2016:1825-1842. doi: 10.1007/978-3-319-18096-0_141.

  • MicroRNA-200c represses IL-6, IL-8, and CCL-5 expression and enhances osteogenic differentiation PLoS ONE. 2016;11 doi: 10.1371/journal.pone.0160915.

  • Continuing Delay in the Diagnosis of Slipped Capital Femoral Epiphysis Journal of Pediatrics. 2016;177:250-254. doi: 10.1016/j.jpeds.2016.06.029.

  • Partial Tears of the Distal Biceps Brachii Tendon: A Systematic Review of Surgical Outcomes Journal of Hand Surgery. 2016;41:e175-e189. doi: 10.1016/j.jhsa.2016.04.019.

  • Management of a Combined Femoral Head and Neck Fracture: A Case Report JBJS Case Connector. 2016;6 doi: 10.2106/JBJS.CC.16.00066.

  • Bavencoffe A., Li Y., Wu Z., Yang Q., Herrera J., Kennedy E., Walters E., Dessauer C. Persistent electrical activity in primary nociceptors after spinal cord injury is maintained by scaffolded adenylyl cyclase and protein kinase A and is associated with altered adenylyl cyclase regulation Journal of Neuroscience. 2016;36(5):1660-1668. doi: 10.1523/JNEUROSCI.0895-15.2016.

  • Ebraheim N., Siddiqui S., Raberding C. A single-incision fasciotomy for compartment syndrome of the lower leg Journal of Orthopaedic Trauma. 2016;30(7):e252-e255. doi: 10.1097/BOT.0000000000000542.

  • Gustafson P., Geeslin A., Jastifer J., Jastifer J. An open source reverse engineering workflow: Geometry to optimization 57th AIAA/ASCE/AHS/ASC Structures, Structural Dynamics, and Materials Conference. 2016

  • Gustafson P., Gustafson P., Geeslin A., Prior D., Chess J. Effect of real-time feedback on screw placement into synthetic cancellous bone Journal of Orthopaedic Trauma. 2016;30:e279-e284. doi: 10.1097/BOT.0000000000000564.

  • Huard J., Lu A., Mu X., Guo P., Li Y. Muscle injuries and repair: What's new on the horizon! Cells Tissues Organs. 2016;202(3-4):227-236. doi: 10.1159/000443926.

  • Jastifer J., Alrafeek S., Howard P., Gustafson P., Coughlin M. Biomechanical Evaluation of Strength and Stiffness of Subtalar Joint Arthrodesis Screw Constructs Foot and Ankle International. 2016;37:419-426. doi: 10.1177/1071100715619680.

  • Jastifer J., Coughlin M. Fibrous Tendon Hypertrophy after Gastrocnemius Recession: A Case Report Journal of Foot and Ankle Surgery. 2016;55:252-254. doi: 10.1053/j.jfas.2014.06.006.

  • Jastifer J., Jastifer J., Marston J. Gastrocnemius Contracture in Patients with and Without Foot Pathology Foot and Ankle International. 2016;37:1165-1170. doi: 10.1177/1071100716659749.

  • Moriarty C., Baker R. A Pain in the Psoas: Groin Injury in a Collegiate Football Athlete Sports Health. 2016;8(6):568-572. doi: 10.1177/1941738116665112.

  • Waizy H., Jastifer J., Stukenborg-Colsman C., Claassen L. The Reverse Ludloff Osteotomy for Bunionette Deformity Foot and Ankle Specialist. 2016;9:324-329. doi: 10.1177/1938640016640886.

  • Traumatic rotator cuff tears Shoulder and Elbow Trauma and its Complications. 2015;1:37-56. doi: 10.1016/B978-1-78242-449-9.00003-0.

  • In vitro study of directly bioprinted perfusable vasculature conduits Biomaterials Science. 2015;3:134-143. doi: 10.1039/c4bm00234b.

  • Microfabrication of scaffold-free tissue strands for three-dimensional tissue engineering Biofabrication. 2015;7 doi: 10.1088/1758-5090/7/3/031002.

  • After the bone and joint decade: It is still time to educate on the musculoskeletal system Journal of Bone and Joint Surgery - American Volume. 2015;97:e6. doi: 10.2106/JBJS.N.01130.

  • Improved biomechanical and biological outcomes in the MRL/MpJ murine strain following a full-length patellar tendon injury Journal of Orthopaedic Research. 2015;33:1693-1703. doi: 10.1002/jor.22928.

  • Superolateral Hoffa's fat pad edema in collegiate volleyball players Journal of Computer Assisted Tomography. 2015;39:945-950. doi: 10.1097/RCT.0000000000000301.

  • Synovial lipomatosis: A rare cause of knee pain in an adolescent female World Journal of Orthopaedics. 2015;6:369-373. doi: 10.5312/wjo.v6.i3.369.

  • Chatterjee S., Yin H., Nam D., Li Y., Ma K. Brain and muscle Arnt-like 1 promotes skeletal muscle regeneration through satellite cell expansion Experimental Cell Research. 2015;331(1):200-210. doi: 10.1016/j.yexcr.2014.08.041.

  • Dall B., Eden S. Outcomes of bilateral sacroiliac joint fusions and the importance of understanding potential coexisting lumbosacral pathology that might also require surgical treatment Acta Orthopaedica Belgica. 2015;81(2):233-239.

  • Jastifer J., Coughlin M. Exposure via sequential release of the metatarsophalangeal joint for plantar plate repair through a dorsal approach without an intraarticular osteotomy Foot and Ankle International. 2015;36:335-338. doi: 10.1177/1071100714553791.

  • Jastifer J., Coughlin M. Hindfoot Deformity and Calcaneal Tuberosity Osteotomies Foot and Ankle Specialist. 2015;8:50-58. doi: 10.1177/1938640014557078.

  • Jastifer J., Coughlin M. Long-term follow-up of mobile bearing total ankle arthroplasty in the United States Foot and Ankle International. 2015;36:143-150. doi: 10.1177/1071100714550654.

  • Jastifer J., Coughlin M., Coughlin M., Hirose C. Performance of total ankle arthroplasty and ankle arthrodesis on uneven surfaces, stairs, and inclines: A prospective study Foot and Ankle International. 2015;36:11-17. doi: 10.1177/1071100714549190.

  • Li Y., Dessauer C. Identifying complexes of adenylyl cyclase with A-kinase anchoring proteins Cyclic Nucleotide Signaling. 2015:147-164. doi: 10.1201/b18477.

  • Macias D., Coughlin M., Zang K., Stevens F., Jastifer J., Doty J. Low-Level Laser Therapy at 635 nm for Treatment of Chronic Plantar Fasciitis: A Placebo-Controlled, Randomized Study Journal of Foot and Ankle Surgery. 2015;54:768-772. doi: 10.1053/j.jfas.2014.12.014.

  • Pan H., Vojnits K., Liu T., Meng F., Yang L., Wang Y., Huard J., Cox C., Lally K., Li Y. MMP1 gene expression enhances myoblast migration and engraftment following implanting into mdx/SCID mice Cell Adhesion and Migration. 2015;9(4):283-292. doi: 10.4161/19336918.2014.983799.

  • Tensmeyer D., Gustafson P., Gustafson P., Jastifer J., Jastifer J., Patel B., Chess J. The effect of load obliquity on the strength of locking and nonlocking constructs in synthetic osteoporotic bone Medical Engineering and Physics. 2015;37:1047-1052. doi: 10.1016/j.medengphy.2015.08.010.

  • Vojnits K., Pan H., Mu X., Li Y. Characterization of an Injury Induced Population of Muscle-Derived Stem Cell-Like Cells Scientific Reports. 2015;5 doi: 10.1038/srep17355.