Peter Dion Pioli, PhD
Assistant Professor, Department of Investigative Medicine
1000 Oakland Drive
Kalamazoo, MI 49008
Peter Pioli, PhD, received his undergraduate degree from the University of Wisconsin-Parkside with an emphasis on molecular biology and bioinformatics. Following a masters degree at the University of California-Irvine, Dr. Pioli earned his doctorate in microbiology and immunology at the University of Utah while studying the role of snail transcription factors in lymphocyte development and function. Dr. Pioli went on to perform his postdoctoral studies in the laboratory of Dr. Kenneth Dorshkind at the University of California-Los Angeles. It is here where he first identified plasma cells as critical regulators of hematopoiesis in the context of aging. Dr. Pioli has his laboratory at the Center for Immunobiology at Western Michigan University Homer Stryker M.D. School of Medicine in Kalamazoo, Michigan. Research in the lab will continue to focus on the transcriptional control of lymphocyte development, functional diversification of plasma cells, as well as the continued study of mechanisms that regulate B lymphopoiesis in the elderly.
Education and Training
- Postdoctoral Research Fellowship 2019, Hematopoiesis , University of California-Los Angeles (UCLA)
- PhD 2015, Microbiology and Immunology, University of Utah
- MS 2010, Molecular Biology, Biochemistry and Genetics, University of California-Irvine
- BS 2006, Molecular Biology and Bioinformatics, University of Wisconsin-Parkside
- Plasma Cells
- Hematopoietic Stem Cells
Dorshkind K., Höfer T., Montecino-Rodriguez E., Pioli P.D., Rodewald H.R. Do haematopoietic stem cells age? Nature Reviews Immunology. 2020;20:196-202. doi: 10.1038/s41577-019-0236-2.
Montecino-Rodriguez E., Kong Y., Casero D., Rouault A., Dorshkind K., Pioli P.D. Lymphoid-Biased Hematopoietic Stem Cells Are Maintained with Age and Efficiently Generate Lymphoid Progeny Stem Cell Reports. 2019;12:584-596. doi: 10.1016/j.stemcr.2019.01.016.
Pioli P.D. Plasma Cells, the Next Generation: Beyond Antibody Secretion Frontiers in Immunology. 2019;10 doi: 10.3389/fimmu.2019.02768.
Pioli P.D., Casero D., Montecino-Rodriguez E., Morrison S.L., Dorshkind K. Plasma Cells Are Obligate Effectors of Enhanced Myelopoiesis in Aging Bone Marrow Immunity. 2019;51:351-366.e6. doi: 10.1016/j.immuni.2019.06.006.
Pioli P., Whiteside S., Weis J., Weis J. Snai2 and Snai3 transcriptionally regulate cellular fitness and functionality of T cell lineages through distinct gene programs Immunobiology. 2016;221:618-633. doi: 10.1016/j.imbio.2016.01.007.
Wang W., Org T., Montel-Hagen A., Pioli P.D., Duan D., Israely E., Malkin D., Su T., Flach J., Kurdistani S.K., Schiestl R.H., Mikkola H.K.A. MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis Nature Communications. 2016;7 doi: 10.1038/ncomms12376.
Pioli P., Chen X., Weis J., Weis J. Fatal autoimmunity results from the conditional deletion of Snai2 and Snai3 Cellular Immunology. 2015;295:1-18. doi: 10.1016/j.cellimm.2015.02.009.
Pioli P., Debnath I., Weis J., Weis J. Zfp318 regulates IgD expression by abrogating transcription termination within the Ighm/Ighd locus Journal of Immunology. 2014;193:2546-2553. doi: 10.4049/jimmunol.1401275.
Pioli P., Weis J. Snail transcription factors in hematopoietic cell development: A model of functional redundancy Experimental Hematology. 2014;42:425-430. doi: 10.1016/j.exphem.2014.03.002.
Debnath I., Roundy K., Pioli P., Weis J., Weis J. Bone marrow-induced Mef2c deficiency delays B-cell development and alters the expression of key B-cell regulatory proteins International Immunology. 2013;25:99-115. doi: 10.1093/intimm/dxs088.
Pioli P., Dahlem T., Weis J., Weis J. Deletion of Snai2 and Snai3 Results in Impaired Physical Development Compounded by Lymphocyte Deficiency PLoS ONE. 2013;8 doi: 10.1371/journal.pone.0069216.
Pioli P., Saleh A., El Fiky A., Nastiuk K., Krolewski J. Sequential proteolytic processing of an interferon-alpha receptor subunit by TNF-alpha converting enzyme and presenilins Journal of Interferon and Cytokine Research. 2012;32:312-325. doi: 10.1089/jir.2011.0116.
Hu Y., Pioli P.D., Siegel E., Zhang Q., Nelson J., Chaturbedi A., Mathews M.S., Ro D.I., Alkafeef S., Hsu N., Hamamura M., Yu L., Hess K.R., Tromberg B.J., Linskey M.E., Zhou Y.H. EFEMP1 suppresses malignant glioma growth and exerts its action within the tumor extracellular compartment. Molecular cancer. 2011;10:123. doi: 10.1186/1476-4598-10-123.
El Fiky A., Pioli P., Azam A., Yoo K., Nastiuk K., Krolewski J. Nuclear transit of the intracellular domain of the interferon receptor subunit IFNaR2 requires Stat2 and Irf9 Cellular Signalling. 2008;20:1400-1408. doi: 10.1016/j.cellsig.2008.03.006.