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Brett W Jagger, MD, PhD
Assistant Professor, Department of Medicine Assistant Professor, Division of Infectious Disease |
Biosketch
Contact Information
WMed1000 Oakland Drive
Kalamazoo, MI 49008
Administrative:
269.337.6350
269.337.4300
Brett Jagger, MD, PhD, is a board-certified physician specializing in infectious diseases. After earning a bachelor's degree in biology from Graceland University, he obtained his medical degree from Indiana University, and a PhD in virology from the University of Cambridge. He subsequently completed residency training in internal medicine at Barnes-Jewish Hospital, and fellowship training in infectious diseases at Washington University, both in St. Louis, Missouri. Dr. Jagger is an assistant professor in the Department of Medicine at Western Michigan University Homer Stryker M.D. School of Medicine. His clinical and research interests include general infectious diseases, including HIV medicine, as well as virology and the pathogenesis of viral illnesses.
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Board Certification
- American Board of Internal Medicine (Internal Medicine)
- American Board of Internal Medicine (Infectious Disease)
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Education and Training
- Clinical Fellowship 2019, Infectious Disease, Washington University in St Louis
- Residency 2015, Internal Medicine, Washington University in St Louis
- PhD 2013, Virology, University of Cambridge
- MD 2013, Indiana University
- BS 2004, Biology, Graceland University
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Research
- Infectious Disease
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Publications
Streblow D.N., Diamond M.S., Moley K., Halabi J., Jagger B.W., Salazar V., Winkler E.S., White J.P., Humphrey P.A., Hirsch A.J. Zika Virus Causes Acute and Chronic Prostatitis in Mice and Macaques Journal of Infectious Diseases. 2020;221:1506-1517. doi: 10.1093/infdis/jiz533.
Bailey T., Shafiuddin M., Gounder A.P., Janowski A.B., Zhao G., Williams G.D., Jagger B.W., Diamondid M.S., Kwon J.H., Wangid D., Boon A.C.M., Bricker T.L. Therapeutic efficacy of favipiravir against bourbon virus in mice PLoS Pathogens. 2019;15 doi: 10.1371/journal.ppat.1007790.
Ewald G., Kwon J., Kosoy O., Hevey M., O'Halloran J., Jagger B., Staples J., Lambert A., Panella A., Turabelidze G., Raymer D. Heartland virus infection in a heart transplant recipient from the Heartland Transplant Infectious Disease. 2019;21 doi: 10.1111/tid.13098.
Jagger B.W., Dowd K.A., Chen R.E., Himansu S., Diamond M.S., Kong W.P., Pierson T.C., Desai P., Foreman B., Burgomaster K.E., Graham B. Protective Efficacy of Nucleic Acid Vaccines Against Transmission of Zika Virus during Pregnancy in Mice Journal of Infectious Diseases. 2019;220:1577-1588. doi: 10.1093/infdis/jiz338.
Kovacikova K., Beard P.M., Hussain S., Turnbull M.L., Wise H.M., Jagger B.W., Taubenberger J.K., Vervelde L., Engelhardt O.G., Digard P. Mutation of influenza A virus PA-X decreases pathogenicity in chicken embryos and can increase the yield of reassortant candidate vaccine viruses Journal of Virology. 2019;93(2) doi: 10.1128/JVI.01551-18.
Salazar V., Jagger B.W., Mongkolsapaya J., Burgomaster K.E., Dejnirattisai W., Winkler E.S., Fernandez E., Nelson C.A., Fremont D.H., Pierson T.C., Screaton G.R., Diamond M.S., Crowe J. Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice Cell Reports. 2019;26(6):1585-1597.e4. doi: 10.1016/j.celrep.2019.01.052.
Slon-Campos J.L., Dejnirattisai W., Jagger B.W., Rey F.A., Diamond M.S., Mongkolsapaya J., Screaton G.R., López-Camacho C., Wongwiwat W., Winkler E.S., Chen R.E., Reyes-Sandoval A., Durnell L.A. A protective Zika virus E-dimer-based subunit vaccine engineered to abrogate antibody-dependent enhancement of dengue infection Nature Immunology. 2019;20:1291-1298. doi: 10.1038/s41590-019-0477-z.
Caine E.A., Jagger B.W., Diamond M.S. Animal models of zika virus infection during pregnancy Viruses. 2018;10(11) doi: 10.3390/v10110598.
Caine E.A., Nunes B.T.D., Medeiros D.B.A., Jagger B.W., Shan C., Fontes C.R., Dowd K.A., Cao B., Muruato A.E., Foreman B.M., Richner J.M., Wang T., Barrett A.D., Weaver S.C., Vasconcelos P.F.C., Rossi S.L., Ciaramella G., Mysorekar I.U., Pierson T.C., Shi P.Y., Diamond M.S., Himansu S., Luo H. Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease Cell. 2017;170(2):273-283.e12. doi: 10.1016/j.cell.2017.06.040.
Cao B., Jagger B.W., Miner J.J., Arora N., Smith A.M., Kovacs A., Mysorekar I.U., Coyne C.B., Diamond M.S. Gestational Stage and IFN-λ Signaling Regulate ZIKV Infection In Utero Cell Host and Microbe. 2017;22(3):366-376.e3. doi: 10.1016/j.chom.2017.08.012.
Hastings A., Hwang J., Uraki R., Gaitsch H., Parnell L., Cao B., Mysorekar I., Rothlin C., Fikrig E., Diamond M., Iwasaki A., Yockey L., Jagger B. TAM Receptors Are Not Required for Zika Virus Infection in Mice Cell Reports. 2017;19(3):558-568. doi: 10.1016/j.celrep.2017.03.058.
Shan C., Muruato A.E., Jagger B.W., Richner J., Nunes J.G.C., Morabito K.M., Kong W.P., Pierson T.C., Barrett A.D., Weaver S.C., Rossi S.L., Vasconcelos P.F.C., Diamond M.S., Nunes B.T.D., Medeiros D.B.A., Xie X., Shi P.Y., Graham B. A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage Nature Communications. 2017;8(1) doi: 10.1038/s41467-017-00737-8.
Turnbull M.L., Wise H.M., Nicol M.Q., Beard P.M., Jagger B.W., Ligertwood Y., Hardisty G.R., Xiao H., Benton D.J., Coburn A.M., Paulo J.A., Gygi S.P., McCauley J.W., Taubenberger J.K., Lycett S.J., Weekes M.P., Dutia B.M., Digard P., Dunfee R., Smith N. Role of the B allele of influenza A virus segment 8 in setting mammalian host range and pathogenicity Journal of Virology. 2016;90(20):9263-9284. doi: 10.1128/JVI.01205-16.
Kash J.C., Davis A.S., Walters K.A., Chertow D.S., Easterbrook J.D., Sandouk A., Jagger B.W., Schwartzman L.M., Wehr N.B., Huffman K., Rosenthal R.A., Ozinsky A., Levine R.L., Doctrow S.R., Taubenberger J.K., Dunfee R., Kuestner R., Xiao Y. Treatment with the reactive oxygen species scavenger EUK-207 reduces lung damage and increases survival during 1918 influenza virus infection in mice Free Radical Biology and Medicine. 2014;67:235-247. doi: 10.1016/j.freeradbiomed.2013.10.014.
Digard P., Jagger B.W., Wise H.M., Holmes E.C., Taubenberger J.K., Shi M. Evolutionary conservation of the PA-X open reading frame in segment 3 of influenza a virus Journal of Virology. 2012;86(22):12411-12413. doi: 10.1128/JVI.01677-12.
Firth A., Jagger B., Wise H., Nelson C., Parsawar K., Wills N., Napthine S., Taubenberger J., Digard P., Atkins J. Ribosomal frameshifting used in influenza A virus expression occurs within the sequence UCC-UUU-CGU and is in the +1 direction Open Biology. 2012;2(OCT) doi: 10.1098/rsob.120109.
Jagger B.W., Wise H.M., Kash J.C., Walters K.A., Wills N.M., Schwartzman L.M., Ozinsky A., Bell G.L., Dalton R.M., Lo A., Efstathiou S., Atkins J.F., Firth A.E., Taubenberger J.K., Digard P., Dunfee R., Xiao Y. An overlapping protein-coding region in influenza A virus segment 3 modulates the host response Science. 2012;337(6091):199-204. doi: 10.1126/science.1222213.
Schwartzman L., Dunham E., Kash J., Taubenberger J., Qi L., Davis A., Jagger B. Analysis by single-gene reassortment demonstrates that the 1918 influenza virus is functionally compatible with a low-pathogenicity avian influenza virus in mice Journal of Virology. 2012;86(17):9211-9220. doi: 10.1128/JVI.00887-12.
Wise H., Hutchinson E., Jagger B., Stuart A., Kang Z., Robb N., Schwartzman L., Kash J., Fodor E., Firth A., Gog J., Taubenberger J., Digard P. Identification of a Novel Splice Variant Form of the Influenza A Virus M2 Ion Channel with an Antigenically Distinct Ectodomain PLoS Pathogens. 2012;8(11) doi: 10.1371/journal.ppat.1002998.
Anderson E., Wise H., Barbezange C., Jagger B., Dalton R., Gog J., Curran M., Taubenberger J., Digard P. Overlapping signals for translational regulation and packaging of influenza A virus segment 2 Nucleic Acids Research. 2011;39(17):7775-7790. doi: 10.1093/nar/gkr487.
Easterbrook J.D., Schwartzman L.M., Jagger B.W., Sandouk A., Kash J.C., Memoli M.J., Taubenberger J.K., Dunfee R. Obese mice have increased morbidity and mortality compared to non-obese mice during infection with the 2009 pandemic H1N1 influenza virus Influenza and other Respiratory Viruses. 2011;5(6):418-425. doi: 10.1111/j.1750-2659.2011.00254.x.
Kash J.C., Walters K.A., Davis A.S., Sandouk A., Schwartzman L.M., Jagger B.W., Chertow D.S., Qi L., Ozinsky A., Taubenberger J.K., Kuestner R. Lethal synergism of 2009 pandemic h1n1 influenza virus and streptococcus pneumoniae coinfection is associated with loss of murine lung repair responses mBio. 2011;2(5) doi: 10.1128/mBio.00172-11.
Qi L., Kash J.C., Dugan V.G., Jagger B.W., Lau Y.F., Sheng Z.M., Crouch E.C., Hartshorn K.L., Taubenberger J.K. The ability of pandemic influenza virus hemagglutinins to induce lower respiratory pathology is associated with decreased surfactant protein D binding Virology. 2011;412(2):426-434. doi: 10.1016/j.virol.2011.01.029.
Jagger B., Memoli M., Hrabal R., Hassantoufighi A., Sheng Z., Eichelberger M., Taubenberger J. Rapid selection of a transmissible multidrug-resistant influenza A/H3N2 virus in an immunocompromised host Journal of Infectious Diseases. 2010;201(9):1397-1403. doi: 10.1086/651610.
Jagger B.W., Memoli M.J., Sheng Z.M., Qi L., Hrabal R.J., Allen G.L., Dugan V.G., Wang R., Digard P., Kash J.C., Taubenberger J.K. The PB2-E627K mutation attenuates viruses containing the 2009 H1N1 influenza pandemic polymerase mBio. 2010;1(1) doi: 10.1128/mBio.00067-10.
Kash J., Qi L., Dugan V., Jagger B., Hrabal R., Memoli M., Morens D., Taubenberger J. Prior infection with classical swine H1N1 influenza viruses is associated with protective immunity to the 2009 pandemic H1N1 virus Influenza and other Respiratory Viruses. 2010;4(3):121-127. doi: 10.1111/j.1750-2659.2010.00132.x.
Memoli M., Jagger B., Dugan V., Qi L., Jackson J., Taubenberger J. Recent human influenza A/H3N2 virus evolution driven by novel selection factors in addition to antigenic drift Journal of Infectious Diseases. 2009;200(8):1232-1241. doi: 10.1086/605893.
Memoli M., Tumpey T., Jagger B., Dugan V., Sheng Z., Qi L., Kash J., Taubenberger J. An early 'classical' swine H1N1 influenza virus shows similar pathogenicity to the 1918 pandemic virus in ferrets and mice Virology. 2009;393(2):338-345. doi: 10.1016/j.virol.2009.08.021.