Kelly M Quesnelle, PhD

Kelly M Quesnelle, PhD
Kelly M Quesnelle, PhD

Associate Professor, Program in Medical Ethics, Humanities, and Law

Associate Professor, Department of Biomedical Sciences


Biosketch

Contact Information

WMed
1000 Oakland Drive
Kalamazoo, MI 49008
Administrative:
Department of Biomedical Sciences
269.337.4552
Program in Medical Ethics, Humanities, and Law
269.337.6068
Kelly.Quesnelle@med.wmich.edu

Kelly Quesnelle, PhD, is an associate professor with the Department of Biomedical Sciences at Western Michigan University Homer Stryker M.D. School of Medicine. She is a graduate of University of Michigan in Ann Arbor, Michigan, and she earned her doctorate with University of Pittsburgh School of Medicine in Pittsburgh, Pennsylvania. In addition, she completed a Postdoctoral Fellowship with the University of Pittsburgh School of Medicine that included training at the United States Food and Drug Administration. She joined WMed in 2014 as a founding faculty member in the Biomedical Science department.

Dr. Quesnelle serves as the pharmacology thread director, responsible for the development and management of the pharmacology curriculum. She also serves as co-director of the Hematology and Oncology course for first year medical students.

  • Education and Training

    • Postdoctoral Fellowship 2014, Vascular Medicine Institute, University of Pittsburgh
    • Fellowship 2013, Cardiovascular and Renal Products, United States Food and Drug Administration
    • PhD 2012, Molecular Pharmacology, University of Pittsburgh
    • BS 2003, Cell & Molecular Biology, University of Michigan-Ann Arbor
  • Language Fluency

    • German, basic
  • Research

    • Pharmacology
    • Molecular Biology
    • Medical Education
  • Publications

    • Hsien Lai S., Zervoudakis G., Chou J., Gurney M.E., Quesnelle K.M. PDE4 subtypes in cancer Oncogene. 2020;39:3791-3802. doi: 10.1038/s41388-020-1258-8.

    • Quesnelle K., Guimaraes D.A., Rao K., Singh A.B., Wang Y., Hogg N., Shiva S. Myoglobin promotes nitrite-dependent mitochondrial S-nitrosation to mediate cytoprotection after hypoxia/reoxygenation Nitric Oxide - Biology and Chemistry. 2020;104-105:36-43. doi: 10.1016/j.niox.2020.08.005.

    • Quesnelle K.M., Montemayor J.R. A Multi-Institutional Study Demonstrating Undergraduate Medical Student Engagement with Question-Type Facebook Posts Medical Science Educator. 2020;30:111-115. doi: 10.1007/s40670-019-00910-2.

    • Braganza A., Quesnelle K., Bickta J., Reyes C., Wang Y., Jessup M., St Croix C., Arlotti J., Singh S.V., Shiva S. Myoglobin induces mitochondrial fusion, thereby inhibiting breast cancer cell proliferation Journal of Biological Chemistry. 2019;294:7269-7282. doi: 10.1074/jbc.RA118.006673.

    • Dickinson B.L., Deming N., Coplit L., Huggett K.N., Quesnelle K., Sheakley M., Rosenfeld G., Wragg S. IAMSE Member Perspectives on the Recognition, Reward, and Promotion of Medical Science Educators: an IAMSE Sponsored Survey Medical Science Educator. 2018;28:335-343. doi: 10.1007/s40670-018-0548-z.

    • Quesnelle K., Bright D., Salvati L. Interprofessional education through a telehealth team based learning exercise focused on pharmacogenomics Currents in Pharmacy Teaching and Learning. 2018;10:1062-1069. doi: 10.1016/j.cptl.2018.05.015.

    • Bystrom P., Foley N., Toledo-Pereyra L., Quesnelle K. Ischemic preconditioning modulates ROS to confer protection in liver ischemia and reperfusion EXCLI Journal. 2017;16:483-496. doi: 10.17179/excli2017-166.

    • Finlayson G., Chavarria M., Chang S., Gardner T., Grande A., MacCallum C., deJong J.L., Quesnelle K. Gabapentin in Mixed Drug Fatalities: Does this Frequent Analyte Deserve More Attention? Academic Forensic Pathology. 2017;7:99-111. doi: 10.23907/2017.012.

    • Keator C., Dickinson B., Lackey W., Morris A., Quesnelle K., Riddle D., Sheakley M., Vanden Heuvel G., Vandre D. Explorations: a New Approach to Self-Directed Learning in a Competency-Based Curriculum Medical Science Educator. 2016;26:777-785. doi: 10.1007/s40670-016-0293-0.

    • Khare A., Raundhal M., Chakraborty K., Das S., Corey C., Kamga C.K., Quesnelle K., St. Croix C., Watkins S.C., Morse C., Oriss T.B., Huff R., Hannum R., Ray P., Ray P., Shiva S., Shiva S., Shiva S., Ray A., Ray A. Mitochondrial H<inf>2</inf>O<inf>2</inf> in Lung Antigen-Presenting Cells Blocks NF-κB Activation to Prevent Unwarranted Immune Activation Cell Reports. 2016;15:1700-1714. doi: 10.1016/j.celrep.2016.04.060.

    • Jones R.T., Toledo-Pereyra L.H., Quesnelle K.M. Selectins in liver ischemia and reperfusion injury Journal of Investigative Surgery. 2015;28:292-300. doi: 10.3109/08941939.2015.1056920.

    • Quesnelle K., Bystrom P., Toledo-Pereyra L. Molecular responses to ischemia and reperfusion in the liver Archives of Toxicology. 2015;89:651-657. doi: 10.1007/s00204-014-1437-x.

    • Quesnelle K., Grandis J., Munger K., Posner M. Head and neck cancer Molecular Oncology: Causes of Cancer and Targets for Treatment. 2015:497-505. doi: 10.1017/CBO9781139046947.043.

    • Khoo N., Mo L., Zharikov S., Kamga-Pride C., Quesnelle K., Golin-Bisello F., Li L., Wang Y., Shiva S., Shiva S. Nitrite augments glucose uptake in adipocytes through the protein kinase A-dependent stimulation of mitochondrial fusion Free Radical Biology and Medicine. 2014;70:45-53. doi: 10.1016/j.freeradbiomed.2014.02.009.

    • Pride C., Mo L., Quesnelle K., Dagda R., Murillo D., Geary L., Corey C., Portella R., Zharikov S., St Croix C., Maniar S., Chu C., K. H. Khoo N., Shiva S., Shiva S. Nitrite activates protein kinase A in normoxia to mediate mitochondrial fusion and tolerance to ischaemia/reperfusion Cardiovascular Research. 2014;101:57-68. doi: 10.1093/cvr/cvt224.

    • Stabile L., He G., Lui V., Henry C., Gubish C., Joyce S., Quesnelle K., Siegfried J., Grandis J., Grandis J. C-Src activation mediates erlotinib resistance in head and neck cancer by stimulating c-Met Clinical Cancer Research. 2013;19:380-392. doi: 10.1158/1078-0432.CCR-12-1555.

    • Stabile L., He G., Lui V., Thomas S., Henry C., Gubish C., Joyce S., Quesnelle K., Siegfried J.",Grandis,"Stabile L., He G., Lui V., Thomas S., Henry C., Gubish C., Joyce S., Quesnelle K., Siegfried J.",Grandis,"Stabile L., He G., Lui V., Thomas S., Henry C., Gubish C., Joyce S., Quesnelle K., Siegfried J.",Grandis,"Stabile L., He G., Lui V., Thomas S., Henry C., Gubish C., Joyce S., Quesnelle K., Siegfried J.",Grandis,"Stabile L., He G., Lui V., Thomas S., Henry C., Gubish C., Joyce S., Quesnelle K., Siegfried J.",Grandis,"Stabile L., He G., Lui V., Thomas S., Henry C., Gubish C., Joyce S., Quesnelle K., Siegfried J.",Grandis,"Stabile L., He G., Lui V., Thomas S., Henry C., Gubish C., Joyce S., Quesnelle K., Siegfried J.",Grandis,"Stabile L., He G., Lui V., Thomas S., Henry C., Gubish C., Joyce S., Quesnelle K., Siegfried J.",Grandis,"Stabile L., He G., Lui V., Thomas S., Henry C., Gubish C., Joyce S., Quesnelle K., Siegfried J.",Grandis} Correction: c-Src activation mediates erlotinib resistance in head and neck cancer by stimulating c-Met (Clinical Cancer Research (2013) 19, (380-392)) Clinical Cancer Research. 2013;19:3715. doi: 10.1158/1078-0432.CCR-13-1344.

    • Quesnelle K.M., Quesnelle K.M., Wheeler S.E., Wheeler S.E., Ratay M., Grandis J.R., Grandis J.R., Grandis J.R., Grandis J.R. Preclinical modeling of EGFR inhibitor resistance in head and neck cancer Cancer Biology and Therapy. 2012;13:935-945. doi: 10.4161/cbt.20846.

    • Quesnelle K., Grandis J., Grandis J. Dual kinase inhibition of EGFR and HER2 overcomes resistance to cetuximab in a novel in vivo model of acquired cetuximab resistance Clinical Cancer Research. 2011;17:5934-5944. doi: 10.1158/1078-0432.CCR-11-0370.

    • Knowles L., Stabile L., Egloff A., Rothstein M., Thomas S., Gubish C., Lerner E., Seethala R., Suzuki S., Quesnelle K., Morgan S., Ferris R., Grandis J., Siegfried J. Correction: HGF and c-Met participate in paracrine tumorigenic pathways in head and neck squamous cell cancer (Clinical Cancer Research (2009) 15, (3740-3750)) Clinical Cancer Research. 2010;16:4298-4300. doi: 10.1158/1078-0432.CCR-10-1729.

    • Yang W., Yang W., Yang W., Cai Q., Lui V.W.Y., Everley P.A., Everley P.A., Kim J., Kim J., Bhola N., Quesnelle K.M., Zetter B.R., Zetter B.R., Steen H., Steen H., Freeman M.R., Freeman M.R., Grandis J.R., Grandis J.R. Quantitative proteomics analysis reveals molecular networks regulated by epidermal growth factor receptor level in head and neck cancer Journal of Proteome Research. 2010;9:3073-3082. doi: 10.1021/pr901211j.

    • Knowles L., Stabile L.P., Egloff A.M., Rothstein M.E., Thomas S.M., Gubish C.T., Lerner E.C., Seethala R.R., Suzuki S., Quesnelle K.M., Morgan S., Ferris R.L., Grandis J.R., Siegfried J.M., Siegfried J.M. HGF and c-Met participate in paracrine tumorigenic pathways in head and neck squamous cell cancer Clinical Cancer Research. 2009;15:3740-3750. doi: 10.1158/1078-0432.CCR-08-3252.

    • Ma C., Quesnelle K.M., Quesnelle K.M., Sparano A., Rao S., Park M., Park M., Cohen M.A., Wang Y., Samanta M., Kumar M.S., Aziz M.U., Naylor T.L., Naylor T.L., Weber B.L., Fakharzadeh S.S., Weinstein G.S., Vachani A., Feldman M.D., Brose M.S., Brose M.S., Brose M.S. Characterization CSMD1 in a large set of primary lung, head and neck, breast and skin cancer tissues Cancer Biology and Therapy. 2009;8:907-916. doi: 10.4161/cbt.8.10.8132.

    • Quesnelle K., Boehm A., Grandis J., Grandis J., Grandis J. STAT-mediated EGFR signaling in cancer Journal of Cellular Biochemistry. 2007;102:311-319. doi: 10.1002/jcb.21475.

    • Sparano A., Quesnelle K.M., Kumar M.S., Wang Y., Sylvester A., Feldman M., Sewell D.A., Weinstein G.S., Brose M.S., Brose M.S., Brose M.S. Genome-wide profiling of oral squamous cell carcinoma by array-based comparative genomic hybridization Laryngoscope. 2006;116:735-741. doi: 10.1097/01.mlg.0000205141.54471.7f.