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Rudolph J Castellani, MD
Adjunct Clinical Professor, Department of Pathology |
Biosketch
Contact Information
WMed1000 Oakland Drive
Kalamazoo, MI 49008
Administrative:
269.337.6173
Rudolph Castellani, MD, is a board-certified pathologist and professor of pathology with Western Michigan University Homer Stryker M.D. School of Medicine in Kalamazoo, Michigan. He is a graduate of Michigan State University in East Lansing, Michigan. He earned his medical degree from Wayne State University School of Medicine in Detroit, Michigan, which is also where he completed his residency in anatomic pathology. He also completed a fellowship in neuropathology with Case Western Reserve University in Cleveland, Ohio.
In addition to Dr. Castellani's board certification in anatomic pathology, he also holds a board certification in neuropathology.
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Board Certification
- American Board of Pathology (Pathology - Anatomic)
- American Board of Pathology (Neuropathology)
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Education and Training
- Fellowship 1995, Neuropathology, Case Western Reserve University
- Residency 1993, Anatomic Pathology, Wayne State University
- MD 1990, Wayne State University
- BS 1986, Physiology, Michigan State University
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Language Fluency
- English, functional
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Publications
Castellani R.J. Preface: Traumatic Brain Injury and Neurodegenerative Disease: A Marriage Made in Sport? Advances in Alzheimer's Disease. 2020;7:VII-X. doi: 10.3233/AIAD7.
Castellani R.J. The significance of tau aggregates in the human brain Brain Sciences. 2020;10:1-14. doi: 10.3390/brainsci10120972.
Castellani R.J., Perry G. Dementia Pugilistica Revisited Advances in Alzheimer's Disease. 2020;7:19-31. doi: 10.3233/AIAD200003.
Castellani R.J., Perry G. Tau Biology, Tauopathy, Traumatic Brain Injury, and Diagnostic Challenges Advances in Alzheimer's Disease. 2020;7:55-75. doi: 10.3233/AIAD200006.
Castellani R.J., Smith M., Bailey K., Perry G., Dejong J.L. Neuropathology in Consecutive Forensic Consultation Cases with a History of Remote Traumatic Brain Injury Advances in Alzheimer's Disease. 2020;7:167-175. doi: 10.3233/AIAD200012.
Castellani R.J., Tripathy A., Shade A., Erskine B., Bailey K., Grande A., Perry G., Dejong J.L. No Evidence of Chronic Traumatic Encephalopathy Pathology or Increased Neurodegenerative Proteinopathy in Former Military Service Members Advances in Alzheimer's Disease. 2020;7:115-126. doi: 10.3233/AIAD200009.
Iverson G.L., Keene C.D., Perry G., Castellani R.J. The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features Advances in Alzheimer's Disease. 2020;7:43-54. doi: 10.3233/AIAD200005.
Iverson G.L., Luoto T.M., Castellani R.J. Authors' reply: Age-Related tau aggregates resemble chronic traumatic encephalopathy neuropathologic change Journal of Neuropathology and Experimental Neurology. 2020;79:924-928. doi: 10.1093/jnen/nlaa047.001.
Muresanu D.F., Sharma A., Sahib S., Tian Z.R., Feng L., Castellani R.J., Nozari A., Lafuente J.V., Buzoianu A.D., Sjöquist P.O., Patnaik R., Wiklund L., Sharma H.S. Diabetes exacerbates brain pathology following a focal blast brain injury: New role of a multimodal drug cerebrolysin and nanomedicine Progress in Brain Research. 2020;258:285-367. doi: 10.1016/bs.pbr.2020.09.004.
Niu F., Sharma A., Wang Z., Feng L., Muresanu D.F., Sahib S., Tian Z.R., Lafuente J.V., Buzoianu A.D., Castellani R.J., Nozari A., Patnaik R., Wiklund L., Sharma H.S. Co-administration of TiO<inf>2</inf>-nanowired DL-3-n-butylphthalide (DL-NBP) and mesenchymal stem cells enhanced neuroprotection in Parkinson's disease exacerbated by concussive head injury Progress in Brain Research. 2020 doi: 10.1016/bs.pbr.2020.09.011.
Sahib S., Sharma A., Menon P.K., Muresanu D.F., Castellani R.J., Nozari A., Lafuente J.V., Bryukhovetskiy I., Tian Z.R., Patnaik R., Buzoianu A.D., Wiklund L., Sharma H.S. Cerebrolysin enhances spinal cord conduction and reduces blood-spinal cord barrier breakdown, edema formation, immediate early gene expression and cord pathology after injury Progress in Brain Research. 2020;258:397-438. doi: 10.1016/bs.pbr.2020.09.012.
Sharma A., Muresanu D.F., Castellani R.J., Nozari A., Lafuente J.V., Sahib S., Tian Z.R., Buzoianu A.D., Patnaik R., Wiklund L., Sharma H.S. Mild traumatic brain injury exacerbates Parkinson's disease induced hemeoxygenase-2 expression and brain pathology: Neuroprotective effects of co-administration of TiO<inf>2</inf> nanowired mesenchymal stem cells and cerebrolysin Progress in Brain Research. 2020;258:157-231. doi: 10.1016/bs.pbr.2020.09.010.
Sharma A., Muresanu D.F., Sahib S., Tian Z.R., Castellani R.J., Nozari A., Lafuente J.V., Buzoianu A.D., Bryukhovetskiy I., Manzhulo I., Patnaik R., Wiklund L., Sharma H.S. Concussive head injury exacerbates neuropathology of sleep deprivation: Superior neuroprotection by co-administration of TiO<inf>2</inf>-nanowired cerebrolysin, alpha-melanocyte-stimulating hormone, and mesenchymal stem cells Progress in Brain Research. 2020;258:1-77. doi: 10.1016/bs.pbr.2020.09.003.
Sharma H.S., Muresanu D.F., Castellani R.J., Nozari A., Lafuente J.V., Tian Z.R., Sahib S., Bryukhovetskiy I., Bryukhovetskiy A., Buzoianu A.D., Patnaik R., Wiklund L., Sharma A. Pathophysiology of blood-brain barrier in brain tumor. Novel therapeutic advances using nanomedicine International Review of Neurobiology. 2020;151:1-66. doi: 10.1016/bs.irn.2020.03.001.
Sharma H.S., Sahib S., Tian Z.R., Muresanu D.F., Nozari A., Castellani R.J., Lafuente J.V., Wiklund L., Sharma A. Protein kinase inhibitors in traumatic brain injury and repair: New roles of nanomedicine Progress in Brain Research. 2020;258:233-283. doi: 10.1016/bs.pbr.2020.09.009.
Castellani R.J., Perry G., Tabaton M. Tau biology, tauopathy, traumatic brain injury, and diagnostic challenges Journal of Alzheimer's Disease. 2019;67:447-467. doi: 10.3233/JAD-180721.
Castellani R.J., Plascencia-Villa G., Perry G. The amyloid cascade and Alzheimer’s disease therapeutics: theory versus observation Laboratory Investigation. 2019;99:958-970. doi: 10.1038/s41374-019-0231-z.
Castellani R.J., Smith M., Bailey K., Perry G., Dejong J.L. Neuropathology in Consecutive Forensic Consultation Cases with a History of Remote Traumatic Brain Injury Journal of Alzheimer's Disease. 2019;72:683-691. doi: 10.3233/JAD-190782.
Iverson G.L., Gardner A.J., Shultz S.R., Solomon G.S., McCrory P., Zafonte R., Perry G., Hazrati L.N., Keene C., Castellani R.J. Chronic traumatic encephalopathy neuropathology might not be inexorably progressive or unique to repetitive neurotrauma Brain. 2019;142:3672-3693. doi: 10.1093/brain/awz286.
Iverson G.L., Luoto T.M., Karhunen P.J., Castellani R.J. Mild chronic traumatic encephalopathy neuropathology in people with no known participation in contact sports or history of repetitive neurotrauma Journal of Neuropathology and Experimental Neurology. 2019;78:615-625. doi: 10.1093/jnen/nlz045.
Ozkizilcik A., Sharma A., Lafuente J.V., Muresanu D.F., Castellani R.J., Nozari A., Tian Z.R., Mössler H., Sharma H.S. Nanodelivery of cerebrolysin reduces pathophysiology of Parkinson's disease Progress in Brain Research. 2019;245:201-246. doi: 10.1016/bs.pbr.2019.03.014.
Sharma A., Castellani R., Smith M., Muresanu D., Dey P., Sharma H. 5-Hydroxytryptophan: A precursor of serotonin influences regional blood-brain barrier breakdown, cerebral blood flow, brain edema formation, and neuropathology International Review of Neurobiology. 2019;146:1-44. doi: 10.1016/bs.irn.2019.06.005.
Sharma H., Feng L., Muresanu D., Castellani R., Sharma A. Neuroprotective effects of a potent bradykinin B2 receptor antagonist HOE-140 on microvascular permeability, blood flow disturbances, edema formation, cell injury and nitric oxide synthase upregulation following trauma to the spinal cord International Review of Neurobiology. 2019;146:103-152. doi: 10.1016/bs.irn.2019.06.008.
Sharma H., Muresanu D., Castellani R., Nozari A., Lafuente J., Tian Z., Ozkizilcik A., Manzhulo I., Mössler H., Sharma A. Nanowired delivery of cerebrolysin with neprilysin and p-Tau antibodies induces superior neuroprotection in Alzheimer's disease Progress in Brain Research. 2019;245:145-200. doi: 10.1016/bs.pbr.2019.03.009.
Sharma H.S., Muresanu D.F., Nozari A., Castellani R.J., Dey P.K., Wiklund L., Sharma A. Anesthetics influence concussive head injury induced blood-brain barrier breakdown, brain edema formation, cerebral blood flow, serotonin levels, brain pathology and functional outcome International Review of Neurobiology. 2019;146:45-81. doi: 10.1016/bs.irn.2019.06.006.
Singh S.K., Srivastav S., Castellani R.J., Plascencia-Villa G., Perry G. Neuroprotective and Antioxidant Effect of Ginkgo biloba Extract Against AD and Other Neurological Disorders Neurotherapeutics. 2019;16:666-674. doi: 10.1007/s13311-019-00767-8.
Tribett T., Erskine B., Bailey K., Brown T., Castellani R. Chronic Traumatic Encephalopathy Pathology After Shotgun Injury to the Brain Journal of Forensic Sciences. 2019;64:1248-1252. doi: 10.1111/1556-4029.14001.
Tripathy A., Shade A., Erskine B., Bailey K., Grande A., Dejong J.J., Perry G., Castellani R.J. No Evidence of Increased Chronic Traumatic Encephalopathy Pathology or Neurodegenerative Proteinopathy in Former Military Service Members: A Preliminary Study Journal of Alzheimer's Disease. 2019;67:1277-1289. doi: 10.3233/JAD-181039.
Wells K., Castellani R., deJong J. Can Neck Contusions in Unexplained Pediatric Deaths be Explained by Cardiopulmonary Resuscitation? Journal of Forensic Sciences. 2019;64:770-772. doi: 10.1111/1556-4029.13919.
Castellani R., Schmidt C. Brain injury biomechanics and abusive head trauma Journal of Forensic Science and Medicine. 2018;4:91-100. doi: 10.4103/jfsm.jfsm_10_18.
Hersh D., Peng S., Dancy J., Galisteo R., Galisteo R., Eschbacher J., Castellani R., Heath J., Legesse T., Kim A., Kim A., Woodworth G., Woodworth G., Tran N., Winkles J., Winkles J., Winkles J. Differential expression of the TWEAK receptor Fn14 in IDH1 wild-type and mutant gliomas Journal of Neuro-Oncology. 2018;138(2):241-250. doi: 10.1007/s11060-018-2799-3.
Isaac C., Cornelison J., Castellani R., deJong J. A Unique Type of Birth Trauma Mistaken for Abuse Journal of Forensic Sciences. 2018;63:602-607. doi: 10.1111/1556-4029.13557.
Iverson G., Keene C., Perry G., Castellani R. The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features Journal of Alzheimer's Disease. 2018;61(1):17-28. doi: 10.3233/JAD-170654.
Patnaik R., Patnaik R., Sharma A., Sharma A., Sharma A., Skaper S., Muresanu D., Muresanu D., Lafuente J., Lafuente J., Lafuente J., Castellani R., Nozari A., Sharma H., Sharma H., Sharma H. Histamine H3 inverse agonist BF 2649 or antagonist with partial h4 agonist activity clobenpropit reduces amyloid beta peptide-induced brain pathology in alzheimer’s disease Molecular Neurobiology. 2018;55:312-321. doi: 10.1007/s12035-017-0743-8.
Patnaik R., Patnaik R., Sharma A., Sharma A., Sharma A., Skaper S., Muresanu D., Muresanu D., Lafuente J., Lafuente J., Lafuente J., Castellani R., Nozari A., Sharma H., Sharma H., Sharma H. Histamine H3 inverse agonist BF 2649 or antagonist with partial h4 agonist activity clobenpropit reduces amyloid beta peptide-induced brain pathology in alzheimer’s disease Molecular Neurobiology. 2018;55(1):312-321. doi: 10.1007/s12035-017-0743-8.
Sharma H., Lafuente J., Muresanu D., Castellani R., Smith M., Nozari A., Patnaik R., Tian Z., Ozkizilcik A., Mössier H., Mössier H., Sharma A. Exacerbation of amyloid beta peptide and tau protein in the cerebrospinal fluid following traumatic brain injury at hot environment neuroproetction by TiO2 nanowired delivery of cerebrolysin with tau antibodies TechConnect Briefs 2018 - Advanced Materials. 2018;3:73-76.
Sharma H., Sharma H., Sharma H., Sharma H., Muresanu D., Muresanu D., Lafuente J., Lafuente J., Lafuente J., Patnaik R., Tian Z., Ozkizilcik A., Castellani R., Mössler H., Sharma A., Sharma A., Sharma A., Sharma A. Co-administration of TiO2 nanowired mesenchymal stem cells with cerebrolysin potentiates neprilysin level and reduces brain pathology in alzheimer’s disease Molecular Neurobiology. 2018;55:300-311. doi: 10.1007/s12035-017-0742-9.
Sharma H., Sharma H., Sharma H., Sharma H., Muresanu D., Muresanu D., Lafuente J., Lafuente J., Lafuente J., Patnaik R., Tian Z., Ozkizilcik A., Castellani R., Mössler H., Sharma A., Sharma A., Sharma A., Sharma A. Co-administration of TiO2 nanowired mesenchymal stem cells with cerebrolysin potentiates neprilysin level and reduces brain pathology in alzheimer’s disease Molecular Neurobiology. 2018;55(1):300-311. doi: 10.1007/s12035-017-0742-9.
Singh S., Srikrishna S., Castellani R., Perry G. Antioxidants in the prevention and treatment of alzheimer’s disease Nutritional Antioxidant Therapies: Treatments and Perspectives. 2018:523-553. doi: 10.1007/978-3-319-67625-8_20.
Tripathy B., Dean S., De Jong D., Schmidt C., Castellani R. Is rotational trauma the only relevant pathogenic mechanism in hemorrhagic retinopathy of shaken baby syndrome? Journal of Forensic Science and Medicine. 2018;4:104-107. doi: 10.4103/jfsm.jfsm_11_18.
Castellani R., Castellani R., Mojica-Sanchez G., Schwartzbauer G., Hersh D. Symptomatic acute-on-chronic subdural hematoma a clinicopathological study American Journal of Forensic Medicine and Pathology. 2017;38(2):126-130. doi: 10.1097/PAF.0000000000000300.
Castellani R., Dejong J., Schmidt C. Homicidal abuse of young children: A historical perspective Journal of Forensic Science and Medicine. 2017;3:97-110. doi: 10.4103/jfsm.jfsm_36_17.
Castellani R., Perry G. Dementia Pugilistica Revisited Journal of Alzheimer's Disease. 2017;60(4):1209-1221. doi: 10.3233/JAD-170669.
Castellani R.J., DeJong J.L., Schmidt C.J. Commentary on: Schuman MJ, Hutchins KD. Severe retinal hemorrhages with retinoschisis in infants are not pathognomonic for abusive head trauma. J Forensic Sci 2017;62(3):807–11 Journal of Forensic Sciences. 2017;62:1677-1678. doi: 10.1111/1556-4029.13628.
Connolly N.P., Connolly N.P., Stokum J.A., Schneider C.S., Ozawa T., Xu S., Galisteo R., Castellani R.J., Kim A.J., Kim A.J., Simard J.M., Simard J.M., Simard J.M., Winkles J.A., Winkles J.A., Holland E., Woodworth G.F., Woodworth G.F. Genetically engineered rat gliomas: PDGFdriven tumor initiation and progression in tv-a transgenic rats recreate key features of human brain cancer PLoS ONE. 2017;12(3) doi: 10.1371/journal.pone.0174557.
Manley G., Gardner A.J., Schneider K.J., Guskiewicz K.M., Bailes J., Cantu R.C., Castellani R.J., Turner M., Jordan B.D., Randolph C., Dvořák J., Alix Hayden K., Tator C.H., McCrory P., Iverson G.L. A systematic review of potential long-term effects of sport-related concussion British Journal of Sports Medicine. 2017;51(12):969-977. doi: 10.1136/bjsports-2017-097791.
McCrory P., Meeuwisse W., Dvorak J., Aubry M., Bailes J., Broglio S., Cantu R.C., Cassidy D., Echemendia R.J., Castellani R.J., Davis G.A., Ellenbogen R., Emery C., Engebretsen L., Feddermann-Demont N., Giza C.C., Guskiewicz K.M., Herring S., Iverson G.L., Johnston K.M., Kissick J., Kutcher J., Leddy J.J., Maddocks D., Makdissi M., Manley G., McCrea M., Meehan W.P., Nagahiro S., Patricios J., Putukian M., Schneider K.J., Sills A., Tator C.H., Turner M., Vos P.E. Infographic: Consensus statement on concussion in sport British journal of sports medicine. 2017;51:1557-1558. doi: 10.1136/bjsports-2017-098065.
McCrory P., Meeuwisse W., Dvořák J., Dvořák J., Aubry M., Bailes J., Broglio S., Cantu R.C., Cassidy D., Echemendia R.J., Echemendia R.J., Castellani R.J., Davis G.A., Davis G.A., Ellenbogen R., Emery C., Engebretsen L., Feddermann-Demont N., Feddermann-Demont N., Giza C.C., Giza C.C., Guskiewicz K.M., Herring S., Iverson G.L., Johnston K.M., Kissick J., Kutcher J., Leddy J.J., Maddocks D., Makdissi M., Makdissi M., Manley G.T., McCrea M., Meehan W.P., Meehan W.P., Nagahiro S., Patricios J., Patricios J., Putukian M., Schneider K.J., Sills A., Sills A., Tator C.H., Tator C.H., Turner M., Vos P.E. Consensus statement on concussion in sport—the 5<sup>th</sup> international conference on concussion in sport held in Berlin, October 2016 British Journal of Sports Medicine. 2017;51(11):838-847. doi: 10.1136/bjsports-2017-097699.
Sajedi P., Gonzalez J., Cronin C., Kouo T., Steven A., Zhuo J., Thompson O., Castellani R., Kittner S., Gandhi D., Raghavan P. Carotid bulb webs as a cause of "cryptogenic" ischemic stroke American Journal of Neuroradiology. 2017;38(7):1399-1404. doi: 10.3174/ajnr.A5208.
Sharma A., Sharma A., Menon P., Menon P., Patnaik R., Muresanu D., Muresanu D., Lafuente J., Tian Z., Ozkizilcik A., Castellani R., Mössler H., Mössler H., Sharma H., Sharma H. Novel Treatment Strategies Using TiO<inf>2</inf>-Nanowired Delivery of Histaminergic Drugs and Antibodies to Tau With Cerebrolysin for Superior Neuroprotection in the Pathophysiology of Alzheimer's Disease International Review of Neurobiology. 2017;137:123-165. doi: 10.1016/bs.irn.2017.09.002.
Sharma H., Sharma H., Sharma H., Sharma H., Muresanu D., Muresanu D., Lafuente J., Lafuente J., Lafuente J., Patnaik R., Tian Z., Ozkizilcik A., Castellani R., Mossier H., Sharma A., Sharma A., Sharma A. Nanodelivery of cerebrolysin reduces depressive stress induced exacerbation of Alzheimer's disease brain pathology following amyloid-beta peptide infusion Advanced Materials - TechConnect Briefs 2017. 2017;3:71-74.
Carvalho C., Correia S., Correia S., Perry G., Perry G., Castellani R., Moreira P., Moreira P. Cerebrovascular and mitochondrial abnormalities in Alzheimer’s disease: a brief overview Journal of Neural Transmission. 2016;123(2):107-111. doi: 10.1007/s00702-015-1367-7.
Castellani R., Castellani R., Mojica G., Perry G. The role of the iron stain in assessing intracranial hemorrhage Open Neurology Journal. 2016;10:136-142. doi: 10.2174/1874205X01610010136.
Castellani R., Correia S., Correia S., Moreira P., Moreira P., Perry G. Tackling Alzheimer's Disease by Targeting Oxidative Stress and Mitochondria Developing Therapeutics for Alzheimer's Disease: Progress and Challenges. 2016:477-502. doi: 10.1016/B978-0-12-802173-6.00018-6.
Hersh D.S., Firempong A.O., Firempong A.O., Chesler D., Chesler D., Castellani R.J., Woodworth G.F. Chondromyxoid fibroma invasion of the transverse-sigmoid sinus junction causing posterior fossa hemorrhage Journal of Clinical Neuroscience. 2016;24:149-150. doi: 10.1016/j.jocn.2015.08.009.
Hersh D.S., Houbova P., Castellani R.J., Rodriguez F.J., Mehta M., Woodworth G.F., Woodworth G.F. Pathologic deposition of non-amyloid immunoglobulin in the brain leading to mass effect and neurological deficits Journal of Clinical Neuroscience. 2016;30:143-145. doi: 10.1016/j.jocn.2016.01.022.
Kelley A., Perry G., Bethea C., Castellani R., Bach S. Molecular mapping Alzheimer’s disease: Maldi imaging of formalin-fixed, paraffin-embedded human hippocampal tissue Open Neurology Journal. 2016;10:88-98. doi: 10.2174/1874205X01610010088.
Kelley A., Perry G., Castellani R., Bach S. Laser-Induced In-Source Decay Applied to the Determination of Amyloid-Beta in Alzheimer's Brains ACS Chemical Neuroscience. 2016;7(3):261-268. doi: 10.1021/acschemneuro.5b00295.
Kvarta M.D., Kvarta M.D., Sharma D., Castellani R.J., Morales R.E., Reich S.G., Kimball A.S., Shin R.K. Demyelination as a harbinger of lymphoma: A case report and review of primary central nervous system lymphoma preceded by multifocal sentinel demyelination BMC Neurology. 2016;16(1) doi: 10.1186/s12883-016-0596-1.
Castellani R. Chronic traumatic encephalopathy: A paradigm in search of evidence? Laboratory Investigation. 2015;95(6):576-584. doi: 10.1038/labinvest.2015.54.
Castellani R., Perry G., Iverson G., Iverson G., Iverson G. Chronic Effects of Mild Neurotrauma: Putting the Cart before the Horse? Journal of Neuropathology and Experimental Neurology. 2015;74(6):493-499. doi: 10.1097/NEN.0000000000000193.
Davis G., Davis G., Castellani R., McCrory P. Neurodegeneration and sport Neurosurgery. 2015;76(6):643-655. doi: 10.1227/NEU.0000000000000722.
Iverson G.L., Gardner A.J., McCrory P., Zafonte R., Castellani R.J. A critical review of chronic traumatic encephalopathy Neuroscience and Biobehavioral Reviews. 2015;56:276-293. doi: 10.1016/j.neubiorev.2015.05.008.
Mehta R., Tosun C., Ivanova S., Tsymbalyuk N., Famakin B., Kwon M., Castellani R., Gerzanich V., Simard J., Simard J., Simard J. Sur1-Trpm4 Cation Channel Expression in Human Cerebral Infarcts Journal of Neuropathology and Experimental Neurology. 2015;74(8):835-849. doi: 10.1097/NEN.0000000000000223.
Mehta R.I., Mehta R.I., Choi J.M., Mukherjee A., Castellani R.J. Hydrophilic polymer embolism and associated vasculopathy of the lung: Prevalence in a retrospective autopsy study Human Pathology. 2015;46(2):191-201. doi: 10.1016/j.humpath.2014.09.011.
Pelcovits A., Marriotti R., Heath J., Perry G., Castellani R.J. Simultaneous Onset of Alzheimer’s Disease in a Husband and Wife in their Mid-Fifties: What do we Really know about Environmental Factors? Open Neurology Journal. 2015;9:1-3. doi: 10.2174/1874205x01509010001.
Shamirian S., Nalbandian A., Khare M., Castellani R., Kim R., Kimonis V.E. Early-onset Alzheimers and cortical vision impairment in a woman with valosin-containing protein disease associated with 2 APOE e4/APOE e4 genotype Alzheimer Disease and Associated Disorders. 2015;29(1):90-93. doi: 10.1097/WAD.0b013e318298e54f.
Surampalli A., Gold B.T., Smith C., Castellani R.J., Khare M., Yu H., Nguyen C., Lan M., Wencel M., Wigal S., Caiozzo V., Kimonis V. A case report comparing clinical, imaging and neuropsychological assessment findings in twins discordant for the VCP p.R155C mutation Neuromuscular Disorders. 2015;25(2):177-183. doi: 10.1016/j.nmd.2014.10.003.
Armstrong M., Castellani R., Reich S. "Rapidly" Progressive Supranuclear Palsy Movement Disorders Clinical Practice. 2014;1:70-72. doi: 10.1002/mdc3.12011.
Blair J., Blair J., Siedlak S., Wolfram J., Nunomura A., Castellani R., Ferreira S., Klein W., Wang Y., Casadesus G., Smith M., Perry G., Zhu X., Lee H. Accumulation of intraneuronal amyloid-β is common in normal brain Current Alzheimer Research. 2014;11(4):317-324. doi: 10.2174/1567205011666140302200902.
Castellani R., Peclovits A., Perry G. Neuropathology of Alzheimer's Disease Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms. 2014:2014-2020. doi: 10.1016/B978-0-12-386456-7.04604-9.
Castellani R., Perry G. Pathogenesis of alzheimer's disease Handbook of Neurotoxicity. 2014;3:2327-2337. doi: 10.1007/978-1-4614-5836-4_162.
Castellani R., Perry G. The complexities of the pathology-pathogenesis relationship in Alzheimer disease Biochemical Pharmacology. 2014;88(4):671-676. doi: 10.1016/j.bcp.2014.01.009.
Choi J., Choi J., Ravipati A., Ravipati A., Nimmagadda V., Nimmagadda V., Schubert M., Castellani R.J., Russell J.W., Russell J.W. Potential roles of PINK1 for increased PGC-1α-mediated mitochondrial fatty acid oxidation and their associations with Alzheimer disease and diabetes Mitochondrion. 2014;18(1):41-48. doi: 10.1016/j.mito.2014.09.005.
Fornicola W., Pelcovits A., Li B., Heath J., Perry G., Castellani R. Alzheimer Disease Pathology in Middle Age Reveals a Spatial-Temporal Disconnect Between Amyloid-β and Phosphorylated Tau Open Neurology Journal. 2014;8:22-26. doi: 10.2174/1874205X01408010022.
Lin J., Heath J.E., Twaddell W.S., Castellani R.J. Undifferentiated sarcoma of the liver: A case study of an erythropoietin-secreting tumor International Journal of Surgical Pathology. 2014;22(6):555-558. doi: 10.1177/1066896913503490.
Palm R., Chang J., Blair J., Garcia-Mesa Y., Lee H., Castellani R., Smith M., Zhu X., Casadesus G., Casadesus G. Down-regulation of serum gonadotropins but not estrogen replacement improves cognition in aged-ovariectomized 3xTg AD female mice Journal of Neurochemistry. 2014;130(1):115-125. doi: 10.1111/jnc.12706.
Perry G., Castellani R. Plaques and tangles: Birthmarks of the aging soul Biochemical Pharmacology. 2014;88(4):423-425. doi: 10.1016/j.bcp.2014.01.028.
Balan I., Balan I., Saladino A., Saladino A., Aarabi B., Castellani R., Wade C., Stein D., Stein D., Eisenberg H., Chen H., Fiskum G., Fiskum G. Cellular alterations in human traumatic brain injury: Changes in mitochondrial morphology reflect regional levels of injury severity Journal of Neurotrauma. 2013;30(5):367-381. doi: 10.1089/neu.2012.2339.
Bonda D., Castellani R., Lee H., Tabaton M., Casadesus G., Perry G., Perry G., Zhu X., Smith M. Down syndrome and Alzheimer disease: A "multi-hit" hypothesis based on multiple contributing factors resulting in pleotrophic consequences Alzheimer's Disease Research Compendium. 2013:183-193.
Castellani R. Challenging issues in brain tumor pathology Pathology Case Reviews. 2013;18(5):209. doi: 10.1097/PCR.0000000000000007.
Castellani R. Diagnostic challenges in surgical neuropathology Pathology Case Reviews. 2013;18(6):243. doi: 10.1097/PCR.0000000000000012.
Choi J., Choi J., Batchu V.V.K., Batchu V.V.K., Schubert M., Castellani R.J., Russell J.W., Russell J.W. A novel PGC-1α isoform in brain localizes to mitochondria and associates with PINK1 and VDAC Biochemical and Biophysical Research Communications. 2013;435(4):671-677. doi: 10.1016/j.bbrc.2013.05.041.
Choi J., Peterson E., Kligerman S., Drachenberg C., Castellani R., Burke A. Hermansky-Pudlak syndrome-associated interstitial pneumonia: Pathologic and imaging findings Pathology Case Reviews. 2013;18(3):111-114. doi: 10.1097/PCR.0b013e3182920481.
Correia S., Correia S., Perry G., Castellani R., Moreira P., Moreira P. Is exercise-in-a-bottle likely to proffer new insights into Alzheimer's disease? Journal of Neurochemistry. 2013;127(1):4-6. doi: 10.1111/jnc.12406.
Fujioka H., Phelix C.F., Friedland R.P., Zhu X., Perry E.A., Castellani R.J., Perry G. Apolipoprotein E4 prevents growth of malaria at the intraerythrocyte stage: Implications for diff erences in racial susceptibility to alzheimer's disease Journal of Health Care for the Poor and Underserved. 2013;24(4 SUPPL.):70-78. doi: 10.1353/hpu.2014.0009.
Hersh D., Mehta R., Woodworth G., Castellani R. The molecular pathology of primary brain tumors Pathology Case Reviews. 2013;18(5):210-220. doi: 10.1097/PCR.0b013e3182a9ac4b.
Huebner T., Kligerman S., Castellani R., Burke A. Nonspecific interstitial pneumonia associated with dermatomyositis with and without anti-jo-1 autoantibodies Pathology Case Reviews. 2013;18(3):127-131. doi: 10.1097/PCR.0b013e31829205e4.
Mehta R., Ivanova S., Tosun C., Castellani R., Gerzanich V., Marc Simard J., Marc Simard J., Marc Simard J. Sulfonylurea receptor 1 expression in human cerebral infarcts Journal of Neuropathology and Experimental Neurology. 2013;72(9):871-883. doi: 10.1097/NEN.0b013e3182a32e40.
Perry E., Castellani R., Moreira P., Nunomura A., Lui Q., Harris P., Sayre L., Szweda P., Szweda L., Zhu X., Smith M., Perry G. Neurofilaments are the major neuronal target of hydroxynonenal-mediated protein cross-links Free Radical Research. 2013;47(6-7):507-510. doi: 10.3109/10715762.2013.794265.
Santos R., Santos R., Correia S., Correia S., Zhu X., Smith M., Moreira P., Moreira P., Castellani R., Nunomura A., Perry G. Mitochondrial DNA oxidative damage and repair in aging and Alzheimer's disease Antioxidants and Redox Signaling. 2013;18(18):2444-2457. doi: 10.1089/ars.2012.5039.
Tannous O., Stall A., Griffith C., Donaldson C., Castellani R., Pellegrini V. Heterotopic bone formation about the hip undergoes endochondral ossification: A rabbit model hip Clinical Orthopaedics and Related Research. 2013;471(5):1584-1592. doi: 10.1007/s11999-013-2801-5.
Tosun C., Kurland D., Mehta R., Castellani R., Dejong J., Kwon M., Woo S., Gerzanich V., Simard J., Simard J., Simard J. Inhibition of the sur1-trpm4 channel reduces neuroinflammation and cognitive impairment in subarachnoid hemorrhage Stroke. 2013;44:3522-3528. doi: 10.1161/STROKEAHA.113.002904.
Williams W.M., Torres S., Siedlak S.L., Castellani R.J., Perry G., Perry G., Smith M.A., Zhu X. Antimicrobial peptide β-defensin-1 expression is upregulated in Alzheimer's brain Journal of Neuroinflammation. 2013;10 doi: 10.1186/1742-2094-10-127.
Castellani R., Moreira P., Perry G., Perry G., Zhu X. The role of iron as a mediator of oxidative stress in Alzheimer disease BioFactors. 2012;38(2):133-138. doi: 10.1002/biof.1010.
Castellani R., Perry G. Pathogenesis and Disease-modifying Therapy in Alzheimer's Disease: The Flat Line of Progress Archives of Medical Research. 2012;43(8):694-698. doi: 10.1016/j.arcmed.2012.09.009.
Kunte H., Busch M., Trostdorf K., Vollnberg B., Harms L., Mehta R., Castellani R., Mandava P., Kent T., Simard J., Simard J., Simard J. Hemorrhagic transformation of ischemic stroke in diabetics on sulfonylureas Annals of Neurology. 2012;72(5):799-806. doi: 10.1002/ana.23680.
Nelson P.T., Nelson P.T., Alafuzoff I., Bigio E.H., Bouras C., Braak H., Cairns N.J., Cairns N.J., Castellani R.J., Crain B.J., Crain B.J., Davies P., Davies P., Tredici K.D., Duyckaerts C., Frosch M.P., Haroutunian V., Hof P.R., Hulette C.M., Hulette C.M., Hyman B.T., Iwatsubo T., Jellinger K., Jicha G.A., Jicha G.A., Kövari E., Kukull W.A., Leverenz J.B., Leverenz J.B., Leverenz J.B., Love S., Love S., Love S., MacKenzie I.R., Mann D.M., Masliah E., Masliah E., McKee A.C., McKee A.C., Montine T.J., Morris J.C., Schneider J.A., Sonnen J.A., Thal D.R., Trojanowski J.Q., Troncoso J.C., Troncoso J.C., Wisniewski T., Woltjer R.L., Beach T.G. Correlation of alzheimer disease neuropathologic changes with cognitive status: A review of the literature Journal of Neuropathology and Experimental Neurology. 2012;71(5):362-381. doi: 10.1097/NEN.0b013e31825018f7.
Nunomura A., Moreira P., Castellani R., Lee H., Zhu X., Smith M., Perry G., Perry G. Oxidative damage to RNA in aging and neurodegenerative disorders Neurotoxicity Research. 2012;22(3):231-248. doi: 10.1007/s12640-012-9331-x.
Perry G., Phelix C.F., Nunomura A., Colom L.V., Castellani R.J., Petersen R.B., Lee H.g., Zhu X. Untangling the vascular web from Alzheimer disease and oxidative stress. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. 2012;39(1):4. doi: 10.1017/s0317167100012609.
Sharma H.S., Sharma H.S., Castellani R.J., Smith M.A., Sharma A. The Blood-Brain Barrier in Alzheimer's Disease. Novel Therapeutic Targets and Nanodrug delivery. International Review of Neurobiology. 2012;102:47-90. doi: 10.1016/B978-0-12-386986-9.00003-X.
Wang X., Wang X., Snape M., Klann E., Stone J., Singh A., Petersen R., Petersen R., Petersen R., Castellani R., Casadesus G., Smith M., Zhu X., Zhu X. Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome Journal of Neurochemistry. 2012;121(4):672-679. doi: 10.1111/j.1471-4159.2012.07722.x.
Williams W., Castellani R., Weinberg A., Perry G., Perry G., Smith M. Do β-defensins and other antimicrobial peptides play a role in neuroimmune function and neurodegeneration? The Scientific World Journal. 2012;2012 doi: 10.1100/2012/905785.
Zhu X., Castellani R., Ziats N., Petersen R., Gon Lee H., Perry G. Mark A. Smith: neurocytochemistry innovator. Journal of neurochemistry. 2012;120(6):1139-1140.
Zhu X., Zhu X., Castellani R., Moreira P., Aliev G., Shenk J., Siedlak S., Harris P., Fujioka H., Sayre L., Szweda P., Szweda L., Smith M., Perry G., Perry G. Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover Free Radical Biology and Medicine. 2012;52(3):699-704. doi: 10.1016/j.freeradbiomed.2011.11.004.
Bonda D., Castellani R., Zhu X., Nunomura A., Lee H., Perry G., Perry G., Smith M. A novel perspective on tau in alzheimer's disease Current Alzheimer Research. 2011;8(6):639-642. doi: 10.2174/156720511796717131.
Castellani R. Comment Neurosurgery. 2011;69(4) doi: 10.1227/NEU.0b013e318223b7a7.
Castellani R., Castellani R., Smith M. Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is 'too big to fail' Journal of Pathology. 2011;224(2):147-152. doi: 10.1002/path.2885.
Castellani R., Gupta Y., Sheng B., Siedlak S., Harris P., Coller J., Perry G., Perry G., Lee H., Tabaton M., Smith M., Wang X., Zhu X. A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: Parallels to stress granules Laboratory Investigation. 2011;91(12):1777-1786. doi: 10.1038/labinvest.2011.149.
Castellani R., Lee H., Petersen R., Zhu X., Perry G. Pathological phenotype in familial neurodegenerative disease: Implications for families and therapeutic constructs Therapy. 2011;8(5):475-479. doi: 10.2217/thy.11.62.
Castellani R., Zhu X., Perry G. Alzheimer's disease therapy: A moving target Therapy. 2011;8(5):457-458. doi: 10.2217/thy.11.56.
Castellani R.J., Nugent S.L., Morrison A., Zhu X., Lee H.G., Harris P.L.R., Bajić V., Sharma H.S., Chen S.G., Oettgen P., Perry G., Perry G., Smith M.A. CD3 in Lewy pathology: Does the abnormal recall of neurodevelopmental processes underlie Parkinson's disease Journal of Neural Transmission. 2011;118(1):23-26. doi: 10.1007/s00702-010-0485-5.
Castellani R.J., Petersen R.B., Lee H.g., Zhu X., Perry G. Mark A. Smith: the scientist, the man. International journal of experimental pathology. 2011;92(5):297-298. doi: 10.1111/j.1365-2613.2011.00785.x.
Hoffman W., Siedlak S., Wang Y., Castellani R., Smith M. Oxidative damage is present in the fatal brain edema of diabetic ketoacidosis Brain Research. 2011;1369:194-202. doi: 10.1016/j.brainres.2010.10.085.
Koltz M., Tosun C., Kurland D., Coksaygan T., Castellani R., Ivanova S., Gerzanich V., Simard J., Simard J., Simard J. Tandem insults of prenatal ischemia plus postnatal raised intrathoracic pressure in a novel rat model of encephalopathy of prematurity: Laboratory investigation Journal of Neurosurgery: Pediatrics. 2011;8(6):628-639. doi: 10.3171/2011.9.PEDS11174.
Perry G., Perry G., Smith M., Casadesus G., Lee H., Moreira P., Castellani R., Zhu X. Using biology to untie the Gordian knot of Alzheimer's disease Journal of Alzheimer's Disease. 2011;23(SUPPL. 1) doi: 10.3233/JAD-2011-001433.
Stone J., Casadesus G., Gustaw Rothenberg K., Siedlak S., Wang X., Zhu X., Perry G., Castellani R., Smith M. Frontiers in Alzheimer's disease therapeutics Therapeutic Advances in Chronic Disease. 2011;2(1):9-23. doi: 10.1177/2040622310382817.
Stone J., Siedlak S., Tabaton M., Hirano A., Castellani R., Santocanale C., Perry G., Smith M., Zhu X., Lee H. The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies Journal of Neuropathology and Experimental Neurology. 2011;70(7):578-587. doi: 10.1097/NEN.0b013e3182204414.
Wang X., Su B., Liu W., He X., Gao Y., Castellani R.J., Perry G., Perry G., Smith M.A., Zhu X. DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: Implications for Parkinson's disease Aging Cell. 2011;10(5):807-823. doi: 10.1111/j.1474-9726.2011.00721.x.
Ziats N., Petersen R., Lee H., Castellani R., Perry G., Zhu X. Mark A. Smith, 1965-2010: Consummate student of pathogenesis International Journal of Clinical and Experimental Pathology. 2011;4(7):731-732.
Bonda D., Castellani R., Lee H., Tabaton M., Casadesus G., Perry G., Perry G., Zhu X., Smith M. Down syndrome and Alzheimer disease: A “multi-hit” hypothesis based on multiple contributing factors resulting in pleotrophic consequences Advances in Genetics Research, Volume 2. 2010:87-97.
Bonda D., Mailankot M., Stone J., Garrett M., Garrett M., Staniszewska M., Staniszewska M., Castellani R., Siedlak S., Zhu X., Lee H., Perry G., Perry G., Nagaraj R., Smith M. Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease Redox Report. 2010;15(4):161-168. doi: 10.1179/174329210X12650506623645.
Castellani R., Rolston R., Smith M. Alzheimer disease Disease-a-Month. 2010;56(9):484-546. doi: 10.1016/j.disamonth.2010.06.001.
Clark T., Lee H., Rolston R., Zhu X., Marlatt M., Marlatt M., Castellani R., Nunomura A., Casadesus G., Smith M., Lee H., Perry G., Perry G. Oxidative stress and its implications for future treatments and management of alzheimer disease International Journal of Biomedical Science. 2010;6(3):225-227.
Fyfe J., Al-Tamimi R., Castellani R., Rosenstein D., Goldowitz D., Henthorn P. Inherited neuroaxonal dystrophy in dogs causing lethal, fetal-onset motor system dysfunction and cerebellar hypoplasia The Journal of comparative neurology. 2010;518(18):3771-3784. doi: 10.1002/cne.22423.
Heath J., Siedlak S., Zhu X., Lee H., Thakur A., Yan R., Perry G., Perry G., Smith M., Castellani R. Widespread distribution of reticulon-3 in various neurodegenerative diseases Neuropathology. 2010;30(6):574-579. doi: 10.1111/j.1440-1789.2010.01107.x.
Lee H., Zhu X., Casadesus G., Castellani R., Nunomura A., Smith M., Lee H., Perry G., Perry G. Antioxidant approaches for the treatment of Alzheimers disease Expert Review of Neurotherapeutics. 2010;10(7):1201-1208. doi: 10.1586/ern.10.74.
Moh C., Siedlak S., Tabaton M., Perry G., Perry G., Castellani R., Smith M. Paraffin-embedded tissue (PET) blot method: Application to Alzheimer disease Journal of Neuroscience Methods. 2010;190(2):244-247. doi: 10.1016/j.jneumeth.2010.05.010.
Mondragón-Rodríguez S., Basurto-Islas G., Lee H., Perry G., Perry G., Zhu X., Castellani R., Smith M. Causes versus effects: The increasing complexities of Alzheimer's disease pathogenesis Expert Review of Neurotherapeutics. 2010;10(5):683-691. doi: 10.1586/ern.10.27.
Rodrigues R., Bonda D.J., Perry G., Castellani R.J., Casadesus G., Lee H.G., Lee H.P., Wang X., Zhu X., Petersen R.B., Smith M.A. Oxidative stress and neurodegeneration: An inevitable consequence of aging? Implications for therapy Brain Protection in Schizophrenia, Mood and Cognitive Disorders. 2010:305-323. doi: 10.1007/978-90-481-8553-5_10.
Shah R., Shin R., Castellani R. Granulocytic sarcoma mimicking HSV encephalitis Neurologist. 2010;16(5):319-321. doi: 10.1097/NRL.0b013e3181b0be8d.
Shvartsbeyn M., Phillips D., Markey M., Morrison A., Dejong J.L., Castellani R.J. Cocaine-induced intracerebral hemorrhage in a patient with cerebral amyloid angiopathy Journal of Forensic Sciences. 2010;55:1389-1392. doi: 10.1111/j.1556-4029.2010.01410.x.
Zou W.Q., Puoti G., Xiao X., Yuan J., Qing L., Cali I., Shimoji M., Langeveld J.P.M., Castellani R., Notari S., Crain B., Schmidt R.E., Geschwind M., DeArmond S.J., Cairns N.J., Dickson D., Honig L., Torres J.M., Mastrianni J., Capellari S., Giaccone G., Belay E.D., Schonberger L.B., Cohen M., Perry G., Kong Q., Parchi P., Tagliavini F., Gambetti P. Variably protease-sensitive prionopathy: A new sporadic disease of the prion protein Annals of Neurology. 2010;68(2):162-172. doi: 10.1002/ana.22094.
Bonda D.J., Evans T., Santocanale C., Llosá J.C., Viña J., Bajic V.P., Castellani R.J., Siedlak S.L., Perry G., Smith M.A., Lee H.g. Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease. Aging. 2009;1(4):382-388. doi: 10.18632/aging.100044.
Cali I., Castellani R., Alshekhlee A., Cohen Y., Blevins J., Yuan J., Langeveld J., Parchi P., Safar J., Zou W., Gambetti P. Co-existence of scrapie prion protein types 1 and 2 in sporadic Creutzfeldt-Jakob disease: Its effect on the phenotype and prion-type characteristics Brain. 2009;132(10):2643-2658. doi: 10.1093/brain/awp196.
Castellani R., Perry G., Perry G., Smith M. Is Alzheimer's disease a myth? When is disease a disease? Current Alzheimer Research. 2009;6(1):82. doi: 10.2174/156720509787313925.
Castellani R., Zhu X., Lee H., Smith M., Perry G., Perry G. Molecular pathogenesis of alzheimer's disease: Reductionist versus expansionist approaches International Journal of Molecular Sciences. 2009;10(3):1386-1406. doi: 10.3390/ijms10031386.
Castellani R.J., Lee H.G., Siedlak S.L., Nunomura A., Hayashi T., Nakamura M., Zhu X., Perry G., Perry G., Smith M.A. Reexamining Alzheimer's disease: Evidence for a protective role for amyloid-β protein precursor and amyloid-β Journal of Alzheimer's Disease. 2009;18(2):447-452. doi: 10.3233/JAD-2009-1151.
Gonzalez-Cuyar L., Tavora F., Caminha I., Perry G., Perry G., Smith M., Castellani R. Cellular respiration and tumor suppressor genes Cellular Respiration and Carcinogenesis. 2009:131-144. doi: 10.1007/978-1-59745-435-3_10.
Gonzalez-Cuyar L., Tavora F., Shaw K., Castellani R., Castellani R., Dejong J. Sudden unexpected death in lymphocytic hypophysitis American Journal of Forensic Medicine and Pathology. 2009;30:61-63. doi: 10.1097/PAF.0b013e3181873851.
Lee H., Casadesus G., Zhu X., Castellani R., McShea A., Perry G., Perry G., Petersen R., Bajic V., Smith M. Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease Neurochemistry International. 2009;54(2):84-88. doi: 10.1016/j.neuint.2008.10.013.
Lee H., Chen Q., Wolfram J., Richardson S., Liner A., Liner A., Siedlak S., Zhu X., Ziats N., Fujioka H., Feisher D., Castellani R., Valencik M., McDonald J., Hoit B., Hoit B., Lesnefsky E., Lesnefsky E., Lesnefsky E., Smith M. Cell cycle re-entry and mitochondrial defects in myc-mediated hypertrophic cardiomyopathy and heart failure PLoS ONE. 2009;4(9) doi: 10.1371/journal.pone.0007172.
Lee H., Lee H., Casadesus G., Nunomura A., Zhu X., Castellani R., Richardson S., Perry G., Perry G., Felsher D., Petersen R., Petersen R., Smith M., Smith M. The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse American Journal of Pathology. 2009;174(3):891-897. doi: 10.2353/ajpath.2009.080583.
Marlatt M.W., Moreira P.I., Lee H.g., Casadesus G., Castellani R.J., Takeda A., Nunomura A., Zhu X., Perry G., Perry G., Smith M.A. Therapeutic opportunities in Alzheimer disease: Current concepts Frontiers in Medicinal Chemistry. 2009;4(1):767-788.
Nunomura A., Hofer T., Moreira P., Castellani R., Smith M., Perry G., Perry G. RNA oxidation in Alzheimer disease and related neurodegenerative disorders Acta Neuropathologica. 2009;118(1):151-166. doi: 10.1007/s00401-009-0508-1.
Nunomura A., Takeda A., Moreira P., Castellani R., Lee H., Zhu X., Smith M., Perry G., Perry G. Neurofibrillary tangle formation as a protective response to oxidative stress in Alzheimer's disease Current Hypotheses and Research Milestones in Alzheimer's Disease. 2009:103-113. doi: 10.1007/978-0-387-87995-6_9.
Stone J., Rolston R., Ueda M., Lee H., Richardson S., Castellani R., Perry G., Perry G., Smith M. Evidence for the novel expression of human Kallikrein-related peptidase 3, prostate-specific antigen, in the brain International Journal of Clinical and Experimental Pathology. 2009;2(3):267-274.
Su B., Liu H., Wang X., Chen S.G., Siedlak S.L., Kondo E., Choi R., Takeda A., Castellani R.J., Perry G., Smith M.A., Zhu X., Lee H.G. Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease Molecular Neurodegeneration. 2009;4(1) doi: 10.1186/1750-1326-4-32.
Bryan K., Lee H., Perry G., Perry G., Castellani R., Smith M., Casadesus G. Nonestrogen-based hormonal therapies for Alzheimer's disease Future Neurology. 2008;3(4):399-407. doi: 10.2217/14796708.3.4.399.
Bryan K., Zhu X., Harris P., Perry G., Perry G., Castellani R., Smith M., Casadesus G. Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease Molecular Neurodegeneration. 2008;3(1) doi: 10.1186/1750-1326-3-13.
Castellani R., Castellani R., Lee H., Zhu X., Perry G., Perry G., Smith M. Alzheimer disease pathology as a host response Journal of Neuropathology and Experimental Neurology. 2008;67(6):523-531. doi: 10.1097/NEN.0b013e318177eaf4.
Castellani R., Castellani R., Nunomura A., Lee H., Perry G., Perry G., Smith M. Phosphorylated tau: Toxic, protective, or none of the above Journal of Alzheimer's Disease. 2008;14(4):377-383. doi: 10.3233/JAD-2008-14404.
Castellani R.J., Nunomura A., Rolston R.K., Moreira P.I., Takeda A., Perry G., Perry G., Smith M.A. Sublethal RNA oxidation as a mechanism for neurodegenerative disease International Journal of Molecular Sciences. 2008;9(5):789-806. doi: 10.3390/ijms9050789.
Evans T., Siedlak S., Lu L., Fu X., Wang Z., McGinnis W., Fakhoury E., Castellani R., Hazen S., Walsh W., Lewis A., Salomon R., Smith M., Perry G., Perry G., Zhu X. The autistic phenotype exhibits a remarkably localized modification of brain protein by products of free radical-induced lipid oxidation American Journal of Biochemistry and Biotechnology. 2008;4(2):61-72. doi: 10.3844/ajbbsp.2008.61.72.
Gambetti P., Gambetti P., Dong Z., Yuan J., Xiao X., Zheng M., Alshekhlee A., Castellani R., Cohen M., Barria M., Gonzalez-Romero D., Belay E., Schonberger L., Marder K., Harris C., Burke J., Montine T., Wisniewski T., Dickson D., Soto C., Hulette C., Mastrianni J., Kong Q., Zou W., Zou W. A novel human disease with abnormal prion protein sensitive to protease Annals of Neurology. 2008;63(6):697-708. doi: 10.1002/ana.21420.
Gonzalez-Cuyar L., Lam-Himlin D., Tavora F., Burke A., Castellani R. Bilateral internal carotid absence: a case report of a rare congenital anomaly Cardiovascular Pathology. 2008;17(2):113-116. doi: 10.1016/j.carpath.2007.04.009.
Gonzalez-Cuyar L.F., Morrison A., Perry G., DeJong J., Smith M.A., Castellani R.J. Cerebrotendinous xanthomatosis: A critical update Future Neurology. 2008;3(4):491-501. doi: 10.2217/14796708.3.4.491.
Gonzalez-Cuyar L.F., Perry G., Perry G., Miyajima H., Atwood C.S., Atwood C.S., Riveros-Angel M., Lyons P.F., Lyons P.F., Siedlak S.L., Smith M.A., Castellani R.J., Castellani R.J. Redox active iron accumulation in aceruloplasminemia Neuropathology. 2008;28(5):466-471. doi: 10.1111/j.1440-1789.2008.00901.x.
Gustaw K., Gustaw K., Garrett M., Lee H., Castellani R., Zagorski M., Prakasam A., Siedlak S., Zhu X., Perry G., Perry G., Petersen R., Friedland R., Smith M., Smith M. Antigen-antibody dissociation in Alzheimer disease: A novel approach to diagnosis Journal of Neurochemistry. 2008;106(3):1350-1356. doi: 10.1111/j.1471-4159.2008.05477.x.
Myung N.H., Myung N.H., Zhu X., Kruman I.I., Castellani R.J., Petersen R.B., Siedlak S.L., Perry G., Perry G., Smith M.A., Lee H.G. Evidence of DNA damage in Alzheimer disease: Phosphorylation of histone H2AX in astrocytes Age. 2008;30(4):209-215. doi: 10.1007/s11357-008-9050-7.
Rolston R., Perry G., Perry G., Zhu X., Castellani R., Dwyer B., Dwyer B., Lee H., Petersen R., Smith M. Iron A pathological mediator of Alzheimer disease? Agro Food Industry Hi-Tech. 2008;19(6):33-36.
Shah R., Lee H., Xiongwei Z., Perry G., Perry G., Smith M., Castellani R. Current approaches in the treatment of Alzheimer's disease Biomedicine and Pharmacotherapy. 2008;62(4):199-207. doi: 10.1016/j.biopha.2008.02.005.
Simard J., Simard J., Simard J., Simard J., Castellani R., Ivanova S., Koltz M., Gerzanich V. Sulfonylurea receptor 1 in the germinal matrix of premature infants Pediatric Research. 2008;64(6):648-652. doi: 10.1203/PDR.0b013e318186e5a9.
Zhu X., Siedlak S., Wang Y., Perry G., Perry G., Castellana R., Cohen M., Smith M., Smith M. Neuronal binucleation in Alzheimer disease hippocampus Neuropathology and Applied Neurobiology. 2008;34(4):457-465. doi: 10.1111/j.1365-2990.2007.00908.x.
Carpenter M., Polk C., Castellani R., Mochoruk K., Sanche S., Stern B., Donnenberg M. Encephalitis of the basal ganglia in an injection drug user. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2007;45(11)
Castellani R. Vascular dementia and Alzheimer's disease: A waning dichotomy Journal of Alzheimer's Disease. 2007;12(4):343-344. doi: 10.3233/JAD-2007-12407.
Castellani R., Castellani R., Lee H., Zhu X., Nunomura A., Perry G., Perry G., Smith M. Alzheimer's disease: Pathology vs etiology International Journal of Neuroprotection and Neuroregeneration. 2007;4(1):36-40.
Castellani R., Moreira P., Liu G., Dobson J., Perry G., Perry G., Smith M., Zhu X. Iron: The redox-active center of oxidative stress in Alzheimer disease Neurochemical Research. 2007;32(10):1640-1645. doi: 10.1007/s11064-007-9360-7.
Castellani R., Zhu X., Lee H., Moreira P., Perry G., Perry G., Smith M. Neuropathology and treatment of Alzheimer disease: Did we lose the forest for the trees? Expert Review of Neurotherapeutics. 2007;7(5):473-485. doi: 10.1586/14737175.7.5.473.
Castellani R.J., Lee H.G., Nunomura A., Zhu X., Perry G., Smith M.A. Protein misfolding in alzheimer’s disease: Pathogenic or protective? Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies. 2007:327-336.
Castellani R.J., Perry G., Perry G., Smith M.A. The role of novel chitin-like polysaccharides in Alzheimer disease Neurotoxicity Research. 2007;12(4):269-274. doi: 10.1007/BF03033910.
Gonzalez-Cuyar L.F., Hunter B., Harris P.L.R., Perry G., Perry G., Smith M.A., Castellani R.J., Castellani R.J. Cerebrotendinous xanthomatosis: Case report with evidence of oxidative stress Redox Report. 2007;12(3):119-124. doi: 10.1179/135100007X200173.
Lee H., Zhu X., Castellani R., Nunomura A., Perry G., Perry G., Smith M., Smith M. Amyloid-β in Alzheimer disease: The null versus the alternate hypotheses Journal of Pharmacology and Experimental Therapeutics. 2007;321(3):823-829. doi: 10.1124/jpet.106.114009.
Nunomura A., Moreira P., Lee H., Zhu X., Castellani R., Smith M., Perry G. Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases CNS and Neurological Disorders - Drug Targets. 2007;6(6):411-423. doi: 10.2174/187152707783399201.
Previll L., Crosby M.E., Castellani R.J., Bowser R., Perry G., Perry G., Smith M.A., Zhu X. Increased expression of p130 in Alzheimer disease Neurochemical Research. 2007;32(4-5):639-644. doi: 10.1007/s11064-006-9146-3.
Cali I., Castellani R., Yuan J., Al-Shekhlee A., Cohen M., Xiao X., Moleres F., Parchi P., Zou W., Gambetti P. Classification of sporadic Creutzfeldt-Jakob disease revisited Brain. 2006;129(9):2266-2277. doi: 10.1093/brain/awl224.
Castellani R., Castellani R., Zhu X., Lee H., Perry G., Perry G., Smith M., Casadesus G. Neurogenesis in human hippocampus: Implications for Alzheimer disease pathogenesis Neuroembryology and Aging. 2006;4(4):175-182. doi: 10.1159/000118927.
Castellani R., Lee H., Perry G., Smith M. Antioxidant protection and neurodegenerative disease: The role of amyloid-β and tau American Journal of Alzheimer's Disease and other Dementias. 2006;21(2):126-130. doi: 10.1177/153331750602100213.
Castellani R., Lee H., Zhu X., Nunomura A., Perry G., Perry G., Smith M. Neuropathology of Alzheimer disease: Pathognomonic but not pathogenic Acta Neuropathologica. 2006;111(6):503-509. doi: 10.1007/s00401-006-0071-y.
Lam-Himlin D., Espey M., Perry G., Perry G., Smith M., Castellani R. Malignant glioma progression and nitric oxide Neurochemistry International. 2006;49(8):764-768. doi: 10.1016/j.neuint.2006.07.001.
Manucha V., Manucha V., Castellani R., Chen C. Alveolar rhabdomyosarcoma of the paranasal sinuses in a 57-year-old woman with 1:16 translocation International Journal of Surgical Pathology. 2006;14(3):238-242. doi: 10.1177/1066896906290560.
Nunomura A., Castellani R., Lee H., Moreira P., Zhu X., Perry G., Smith M. Neuropathology in Alzheimer's disease: awaking from a hundred-year-old dream. Science of aging knowledge environment : SAGE KE. 2006;2006(8) doi: 10.1126/sageke.2006.8.pe10.
Nunomura A., Castellani R., Zhu X., Moreira P., Perry G., Perry G., Smith M., Smith M. Involvement of oxidative stress in Alzheimer disease Journal of Neuropathology and Experimental Neurology. 2006;65(7):631-641. doi: 10.1097/01.jnen.0000228136.58062.bf.
Smith M.A., Zhu X., Lee H.G., Harris P.L.R., Fortino A., Perry G., Castellani R.J. Sequestration of p27 within the cytoplasm of cardiac myocytes in chronic ischemic heart disease: Pathogenic implications for ischemic cardiomyopathy Age. 2006;28(1):85-91. doi: 10.1007/s11357-006-9001-0.
Castellani R., Nunomura A., Lee H., Zhu X., Perry G., Smith M. Amyloid-β and τ in alzheimerߣs disease: What is the neuropathology trying to tell us? Oxidative Stress and Age-Related Neurodegeneration. 2005:121-130.
Castellani R.J., Siedlak S.L., Fortino A., Perry G., Ghetti B., Smith M.A. Chitin-like polysaccharides in Alzheimer's disease brains Current Alzheimer Research. 2005;2(4):419-423. doi: 10.2174/156720505774330555.
He Q., Lowrie C., Shelton G.D., Castellani R.J., Menotti-Raymond M., Murphy W., O'Brien S.J., Swanson W.F., Fyfe J.C., Fyfe J.C., Fyfe J.C. Inherited motor neuron disease in domestic cats: A model of spinal muscular atrophy Pediatric Research. 2005;57(3):324-330. doi: 10.1203/01.PDR.0000153625.46892.6F.
Lee H., Castellani R., Zhu X., Perry G., Smith M., Smith M. Amyloid-β in Alzheimer's disease: The horse or the cart? Pathogenic or protective? International Journal of Experimental Pathology. 2005;86(3):133-138. doi: 10.1111/j.0959-9673.2005.00429.x.
Moreira P., Moreira P., Smith M., Zhu X., Nunomura A., Castellani R., Perry G., Perry G. Oxidative stress and neurodegeneration Annals of the New York Academy of Sciences. 2005;1043:545-552. doi: 10.1196/annals.1333.062.
Petersen R., Siedlak S., Lee H., Kim Y., Nunomura A., Tagliavini F., Ghetti B., Cras P., Moreira P., Castellani R., Guentchev M., Budka H., Ironside J., Gambetti P., Smith M., Perry G. Redox metals and oxidative abnormalities in human prion diseases Acta Neuropathologica. 2005;110(3):232-238. doi: 10.1007/s00401-005-1034-4.
Aliev G., Aliev G., Castellani R.J., Petersen R.B., Burnstock G., Perry G., Smith M.A. Pathobiology of familial hypercholesterolemic atherosclerosis Journal of Submicroscopic Cytology and Pathology. 2004;36(3-4):225-240.
Castellani R. Variant creutzfeldt-jakob disease: An overview Pathology Case Reviews. 2004;9(1):16-19. doi: 10.1097/01.pcr.0000109252.46656.95.
Castellani R., Colucci M., Xie Z., Zou W., Li C., Parchi P., Capellari S., Pastore M., Rahbar M., Chen S., Gambetti P., Gambetti P. Sensitivity of 14-3-3 protein test varies in subtypes of sporadic Creutzfeldt-Jakob disease Neurology. 2004;63(3):436-442. doi: 10.1212/01.WNL.0000135153.96325.3B.
Castellani R., Honda K., Zhu X., Cash A., Nunomura A., Perry G., Smith M. Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease Ageing Research Reviews. 2004;3(3):319-326. doi: 10.1016/j.arr.2004.01.002.
Castellani R., Perry G., Smith M. Prion disease and Alzheimer's disease: Pathogenic overlap Acta Neurobiologiae Experimentalis. 2004;64(1):11-17.
Castellani R., Smith M., Perry G., Friedland R. Cerebral amyloid angiopathy: Major contributor or decorative response to Alzheimer's disease pathogenesis Neurobiology of Aging. 2004;25(5):599-602. doi: 10.1016/j.neurobiolaging.2003.12.019.
Ghanbari H., Ghanbari K., Harris P., Jones P., Kubat Z., Castellani R., Castellani R., Wolozin B., Smith M., Perry G. Oxidative damage in cultured human olfactory neurons from Alzheimer's disease patients Aging Cell. 2004;3(1):41-44. doi: 10.1111/j.1474-9728.2004.00083.x.
Huang L., Hollingsworth R., Castellani R., Zipser B. Accumulation of high-molecular-weight amylose in Alzheimer's disease brains Glycobiology. 2004;14(5):409-416. doi: 10.1093/glycob/cwh042.
Lee H., Ogawa O., Zhu X., O'Neil M., Petersen R., Castellani R., Ghanbari H., Perry G., Smith M. Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer's disease Acta Neuropathologica. 2004;107(4):365-371. doi: 10.1007/s00401-004-0820-8.
Zhu X., McShea A., Harris P., Raina A., Castellani R., Funk J., Shah S., Atwood C., Atwood C., Bowen R., Bowser R., Morelli L., Perry G., Smith M., Smith M. Elevated Expression of a Regulator of the G2/M Phase of the Cell Cycle, Neuronal CIP-1-Associated Regulator of Cyclin B, in Alzheimer's Disease Journal of Neuroscience Research. 2004;75(5):698-703. doi: 10.1002/jnr.20028.
Cash A.D., Aliev G., Siedlak S.L., Nunomura A., Fujioka H., Zhu X., Raina A.K., Vinters H.V., Tabaton M., Johnson A.B., Paula-Barbosa M., Avíla J., Jones P.K., Castellani R.J., Castellani R.J., Smith M.A., Perry G. Microtubule reduction in Alzheimer's disease and aging is independent of τ filament formation American Journal of Pathology. 2003;162(5):1623-1627. doi: 10.1016/S0002-9440(10)64296-4.
Krefft T., Graff-Radford N., Graff-Radford N., Dickson D., Baker M., Castellani R. Familial primary progressive aphasia Alzheimer Disease and Associated Disorders. 2003;17(2):106-112. doi: 10.1097/00002093-200304000-00009.
Ogawa O., Lee H., Zhu X., Raina A., Harris P., Castellani R., Perry G., Smith M. Increased p27, an essential component of cell cycle control, in Alzheimer's disease. Aging cell. 2003;2(2):105-110. doi: 10.1046/j.1474-9728.2003.00042.x.
Ogawa O., Zhu X., Lee H.G., Raina A., Obrenovich M.E., Bowser R., Ghanbari H.A., Castellani R.J., Perry G., Smith M.A. Ectopic localization of phosphorylated histone H3 in Alzheimer's disease: A mitotic catastrophe? Acta Neuropathologica. 2003;105(5):524-528. doi: 10.1007/s00401-003-0684-3.
Perry G., Castellani R., Smith M., Harris P., Kubat Z., Ghanbari K., Jones P., Cordone G., Tabaton M., Wolozin B., Ghanbari H. Oxidative damage in the olfactory system in Alzheimer's disease Acta Neuropathologica. 2003;106(6):552-556. doi: 10.1007/s00401-003-0761-7.
Perry G., Taddeo M., Petersen R., Castellani R., Harris P., Siedlak S., Cash A., Liu Q., Nunomura A., Atwood C., Smith M. Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease BioMetals. 2003;16(1):77-81. doi: 10.1023/A:1020731021276.
Bowen R., Smith M., Harris P., Kubat Z., Martins R., Castellani R., Perry G., Atwood C., Atwood C. Elevated luteinizing hormone expression colocalizes with neurons vulnerable to Alzheimer's disease pathology Journal of Neuroscience Research. 2002;70(3):514-518. doi: 10.1002/jnr.10452.
Castellani R., Castellani R., Hirai K., Aliev G., Drew K.L., Nunomura A., Takeda A., Cash A.D., Obrenovich M.E., Perry G., Smith M.A., Smith M.A. Role of mitochondrial dysfunction in Alzheimer's disease Journal of Neuroscience Research. 2002;70(3):357-360. doi: 10.1002/jnr.10389.
Castellani R., Perry G., Siedlak S., Nunomura A., Shimohama S., Zhang J., Montine T., Sayre L., Smith M. Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans Neuroscience Letters. 2002;319(1):25-28. doi: 10.1016/S0304-3940(01)02514-9.
Guentchev M., Siedlak S., Jarius C., Tagliavini F., Castellani R., Perry G., Smith M., Budka H. Oxidative damage to nucleic acids in human prion disease Neurobiology of Disease. 2002;9(3):275-281. doi: 10.1006/nbdi.2002.0477.
Hartzler A.W., Zhu X., Siedlak S.L., Castellani R.J., Avilá J., Perry G., Smith M.A. The p38 pathway is activated in Pick disease and progressive supranuclear palsy: A mechanistic link between mitogenic pathways, oxidative stress, and tau Neurobiology of Aging. 2002;23(5):855-859. doi: 10.1016/S0197-4580(02)00029-5.
Kikuchi A., Takeda A., Onodera H., Kimpara T., Kimpara T., Hisanaga K., Sato N., Nunomura A., Castellani R., Perry G., Smith M., Itoyama Y. Systemic increase of oxidative nucleic acid damage in Parkinson’s disease and multiple system atrophy Neurobiology of Disease. 2002;9(2):244-248. doi: 10.1006/nbdi.2002.0466.
Nunomura A., Chiba S., Chiba S., Kosaka K., Kosaka K., Takeda A., Takeda A., Castellani R., Castellani R., Smith M., Smith M., Perry G., Perry G. Neuronal RNA oxidation is a prominent feature of dementia with Lewy bodies NeuroReport. 2002;13(16):2035-2039. doi: 10.1097/00001756-200211150-00009.
Perry G., Nunomura A., Nunomura A., Hirai K., Hirai K., Zhu X., Prez M., Avila J., Castellani R.J., Atwood C.S., Aliev G., Sayre L.M., Takeda A., Takeda A., Smith M.A., Smith M.A. Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases? Free Radical Biology and Medicine. 2002;33(11):1475-1479. doi: 10.1016/S0891-5849(02)01113-9.
Perry G., Perry G., Sayre L., Atwood C., Castellani R., Cash A., Rottkamp C., Smith M. The role of iron and copper in the aetiology of neurodegenerative disorders: Therapeutic implications CNS Drugs. 2002;16(5):339-352. doi: 10.2165/00023210-200216050-00006.
Perry G., Taddeo M.A., Nunomura A., Zhu X., Zenteno-Savin T., Drew K.L., Shimohama S., Avila J., Castellani R.J., Smith M.A. Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: Beyond damage and response Comparative Biochemistry and Physiology - C Toxicology and Pharmacology. 2002;133(4):507-513. doi: 10.1016/S1532-0456(02)00119-9.
Sarode V., Sarode V., Castellani R., Post A. Fine-needle aspiration cytology and differential diagnoses of fibrolamellar hepatocellular carcinoma metastatic to the mediastinum: Case report Diagnostic Cytopathology. 2002;26(2):95-98. doi: 10.1002/dc.10047.
Yfantis H., Nonaka D., Castellani R., Harman C., Sun C.C., Sun C.C. Heterogeneity in fetal akinesia deformation sequence (FADS): Autopsy confirmation in three 20-21-week fetuses Prenatal Diagnosis. 2002;22(1):42-47. doi: 10.1002/pd.234.
Zhou F., Braddock J., Hu Y., Zhu X., Castellani R., Smith M., Drew K. Microbial origin of glutamate, hibernation and tissue trauma: An in vivo microdialysis study Journal of Neuroscience Methods. 2002;119(2):121-128. doi: 10.1016/S0165-0270(02)00177-2.
Castellani R., Harris P., Sayre L., Fujii J., Taniguchi N., Vitek M., Founds H., Atwood C., Perry G., Perry G., Smith M. Active glycation in neurofibrillary pathology of Alzheimer disease: N<sup>ε</sup>-(Carboxymethyl) lysine and hexitol-lysine Free Radical Biology and Medicine. 2001;31(2):175-180. doi: 10.1016/S0891-5849(01)00570-6.
Raina A.K., Hochman A., Zhu X., Rottkamp C.A., Nunomura A., Siedlak S.L., Boux H., Castellani R.J., Perry G., Smith M.A. Abortive apoptosis in Alzheimer's disease Acta Neuropathologica. 2001;101(4):305-310. doi: 10.1007/s004010100378.
Smith M., Perry G., Castellani R. FTD and ADHD: Pathology versus pathophysiology Neurology Psychiatry and Brain Research. 2001;9(3):137-138.
Zhou F., Zhu X., Castellani R., Stimmelmayr R., Perry G., Smith M., Drew K., Drew K. Hibernation, a model of neuroprotection American Journal of Pathology. 2001;158(6):2145-2151. doi: 10.1016/S0002-9440(10)64686-X.
Zhu X., Castellani R., Takeda A., Nunomura A., Atwood C., Perry G., Smith M. Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: The 'two hit' hypothesis Mechanisms of Ageing and Development. 2001;123(1):39-46. doi: 10.1016/S0047-6374(01)00342-6.
Castellani R., Harris P., Lecroisey A., Izadi-Pruneyre N., Wandersman C., Perry G., Smith M., Smith M. Evidence for a novel heme-binding protein, HasAh, in Alzheimer disease Antioxidants and Redox Signaling. 2000;2(1):137-142. doi: 10.1089/ars.2000.2.1-137.
Castellani R., Siedlak S., Perry G., Smith M. Sequestration of iron by Lewy bodies in Parkinson's disease Acta Neuropathologica. 2000;100(2):111-114. doi: 10.1007/s004010050001.
Mackowiak P.A., Boulware L.E., Pogue D.H., Rastegar D.A., Castellani R.J. A 78-year-old woman with leg pain and weakness American Journal of the Medical Sciences. 2000;319(6):404-410. doi: 10.1016/s0002-9629(15)40782-7.
Brat D., Brat D., James C., Jedlicka A., Connolly D., Chang E., Castellani R., Schmid M., Schiller M., Carson D., Burger P. Molecular genetic alterations in radiation-induced astrocytomas American Journal of Pathology. 1999;154(5):1431-1438. doi: 10.1016/S0002-9440(10)65397-7.
Castellani R., Castellani R., Perry G., Brenner D., Smith M. Alexander disease: Alzheimer disease of the developing brain? Alzheimer Disease and Associated Disorders. 1999;13(4):232-235. doi: 10.1097/00002093-199910000-00010.
Castellani R., Smith M., Nunomura A., Nunomura A., Harris P., Perry G. Is increased redox-active iron in Alzheimer disease a failure of the copper-binding protein ceruloplasmin Free Radical Biology and Medicine. 1999;26(11-12):1508-1512. doi: 10.1016/S0891-5849(99)00016-7.
Gerst J., Siedlak S., Nunomura A., Castellani R., Perry G., Smith M., Smith M. Role of oxidative stress in frontotemporal dementia Dementia and Geriatric Cognitive Disorders. 1999;10(SUPPL. 1):85-87. doi: 10.1159/000051220.
Castellani R. Multiple system atrophy: Clues from inclusions American Journal of Pathology. 1998;153(3):671-676. doi: 10.1016/S0002-9440(10)65608-8.
Castellani R., Perry G., Harris P., Cohen M., Sayre L., Salomon R., Smith M. Advanced lipid peroxidation end-products in Alexander's disease Brain Research. 1998;787(1):15-18. doi: 10.1016/S0006-8993(97)01224-9.
Perry G., Castellani R., Hirai K., Smith M. Reactive oxygen species mediate cellular damage in Alzheimer disease Journal of Alzheimer's Disease. 1998;1(1):45-55. doi: 10.3233/JAD-1998-1103.
Smith M., Smith M., Vašák M., Knipp M., Castellani R., Perry G. Dimethylargininase, a nitric oxide regulatory protein, in Alzheimer disease Free Radical Biology and Medicine. 1998;25(8):898-902. doi: 10.1016/S0891-5849(98)00119-1.
Zagardo M., Zagardo M., Castellani R., Rees J., Rothman M., Zoarski G. Radiologic and pathologic findings of intracerebral Schwannoma American Journal of Neuroradiology. 1998;19(7):1290-1293.
Castellani R., Parchi P., Madoff L., Gambetti P., Mckeever P. Biopsy diagnosis of Creutzfeldt-Jakob disease by western blot: A case report Human Pathology. 1997;28(5):623-626. doi: 10.1016/S0046-8177(97)90086-1.
Castellani R., Perry G., Harris P., Monnier V., Cohen M., Smith M. Advanced glycation modification of rosenthal fibers in patients with Alexander disease Neuroscience Letters. 1997;231(2):79-82. doi: 10.1016/S0304-3940(97)00521-1.
Cortelli P., Cortelli P., Perani D., Parchi P., Grassi F., Montagna P., De Martin M., Castellani R., Tinuper P., Gambetti P., Lugaresi E., Fazio F. Cerebral metabolism in fatal familial insomnia: Relation to duration, neuropathology, and distribution of protease-resistant prion protein Neurology. 1997;49(1):126-133. doi: 10.1212/WNL.49.1.126.
Drachenberg C.B., Ioffe O.B., Castellani R.J., Papadimitriou J.C. Nuclear bcl-2 staining in tumors. American journal of clinical pathology. 1997;108(4):479. doi: 10.1093/ajcp/108.4.479.
Zagardo M., Zagardo M., Castellani R., Zoarski G., Bauserman S. Granulomatous amebic encephalitis caused by leptomyxid amebae in an HIV- infected patient American Journal of Neuroradiology. 1997;18(5):903-908.
Castellani R., Castellani R., Parchi P., Stahl J., Capellari S., Cohen M., Gambetti P. Early pathologic and biochemical changes in Creutzfeldt-Jakob disease: Study of brain biopsies Neurology. 1996;46(6):1690-1693. doi: 10.1212/WNL.46.6.1690.
Castellani R., Smith M., Richey P., Perry G. Glycoxidation and oxidative stress in Parkinson disease and diffuse Lewy body disease Brain Research. 1996;737(1-2):195-200. doi: 10.1016/0006-8993(96)00729-9.
Gallassi R., Gallassi R., Morreale A., Montagna P., Cortelli P., Avoni P., Castellani R., Gambetti P., Lugaresi E. Fatal familial insomnia: Behavioral and cognitive features Neurology. 1996;46(4):935-939. doi: 10.1212/WNL.46.4.935.
Kim P., Castellani R., Tresser N. Cerebral venous malformation complicated by spontaneous thrombosis Child's Nervous System. 1996;12(3):172-175. doi: 10.1007/BF00266825.
Parchi P., Castellani R., Capellari S., Ghetti B., Ghetti B., Young K., Chen S.G., Farlow M., Dickson D.W., Sima A.A.F., Trojanowski J.Q., Petersen R.B., Gambetti P., Gambetti P. Molecular basis of phenotypic variability in sporadic Creutzfeldt-Jakob disease Annals of Neurology. 1996;39(6):767-778. doi: 10.1002/ana.410390613.
Castellani R., Smith M., Richey P., Kalaria R., Gambetti P., Perry G. Evidence for oxidative stress in Pick disease and corticobasal degeneration Brain Research. 1995;696(1-2):268-271. doi: 10.1016/0006-8993(95)00535-X.
Hedera P., Lerner A., Castellani R., Friedland R. Concurrence of Alzheimer's disease, Parkinson's disease, diffuse Lewy body disease, and amyotrophic lateral sclerosis Journal of the Neurological Sciences. 1995;128(2):219-224. doi: 10.1016/0022-510X(94)00222-A.
Parchi P., Castellani R., Cortelli P., Montagna P., Chen S., Petersen R., Manetto V., Vnencak‐Jones C., McLean M., McLean M., Sheller J., Lugaresi E., Autilio‐Gambetti L., Gambetti P. Regional distribution of protease‐resistant prion protein in fatal familial insomnia Annals of Neurology. 1995;38(1):21-29. doi: 10.1002/ana.410380107.
Premkumar D., Smith M., Richey P., Petersen R., Castellani R., Kutty R., Wiggert B., Perry G., Kalaria R., Kalaria R. Induction of Heme Oxygenase‐1 mRNA and Protein in Neocortex and Cerebral Vessels in Alzheimer's Disease Journal of Neurochemistry. 1995;65(3):1399-1402. doi: 10.1046/j.1471-4159.1995.65031399.x.
Castellani R., Visscher D., Wykes S., Sarkar F., Crissman J. Interaction of transforming growth factor‐alpha and epidermal growth factor receptor in breast carcinoma. An immunohistologic study Cancer. 1994;73(2):344-349. doi: 10.1002/1097-0142(19940115)73:2<344::AID-CNCR2820730218>3.0.CO;2-Y.
Visscher D., Castellani R., Wykes S., Sarkar F., Hussain M. Concurrent abnormal expression of ERBB-2, EGFR, and p53 genes and clinical disease progression of breast carcinoma Breast Cancer Research and Treatment. 1993;28(3):261-266. doi: 10.1007/BF00666587.