
Professor, Department of Biomedical Sciences
Biosketch
Mireya Diaz, PhD, has over 15 years of statistical consulting experience. She received her doctorate degree in Biostatistics from Case Western Reserve University. There she served as an Assistant Professor of Biostatistics, member of two NIH-funded biostatistics core - one as Director - and Director of the Biostatistics program. While in this position she also worked as a methodologist for the Guidelines Department of the American Urological Association providing the methodological rigor for the medical guidelines dealing with management of VUR in children. Then she accepted a position as Associate Scientist and Director of Biostatistics of the Vattikuti Urology Institute where she worked with the Menon's pioneering team of Robotic Prostatectomy generating the evidence for the comparative effectiveness of the robotic approach. Her research endeavors and contributions to science focus in the development, application, and evaluation of statistical methods for effectiveness research with large observational databases including disease registries, administrative claims, and EMRs; meta-analyses of complex outcome structures; health technology assessment and medical guidelines development; and correlated data.
-
Education and Training
- PhD 2002, Biostatistics, Graduate School, Case Western Reserve University
- MSc 1999, Biomedical Engineering, Graduate School, Case Western Reserve University
- BSc 1994, Electrical Engineering, Engineering, Universidad Metropolitana
-
Research
- Statistical Consulting
- Spatial Statistics
- Research Methods/Statistics
- Meta-Analysis
- Markov Chains
- Epidemiology and Health Services Research Related to Benign Urologic Diseases
- Electronic Health Record Systems
- Cancer Treatment Decision Making
-
Publications
Alhamar M., Jabbar A., Deebajah M., Diaz M., Alanee S., Hassan O., Williamson S.R., Schultz D., Gupta N. Prognostic significance of histomorphologic features of lymph node metastases in prostate cancer patients treated with radical prostatectomy: A single center study Urologic Oncology: Seminars and Original Investigations. 2021;39:829.e1-829.e8.
Tsafrir Z., Janosek-Albright K., Aoun J., Diaz-Insua M., Abd-El-Barr A.E.R., Schiff L., Talukdar S., Menon M., Munkarah A., Theoharis E., Eisenstein D. The impact of a wireless audio system on communication in robotic-assisted laparoscopic surgery: A prospective controlled trial PLoS ONE. 2020;15
Dalela D., Sun M., Diaz M., Karabon P., Seisen T., Trinh Q.D., Menon M., Abdollah F. Contemporary Trends in the Incidence of Metastatic Prostate Cancer Among US Men: Results from Nationwide Analyses European Urology Focus. 2019;5:77-80.
Lima N.d.A., Stancic C., Vos D., Carmen Diaz Insua M.M.D., Lima C.C.d.V., de Castro R.L., Maravelas R., Melgar T.A. Hospital admissions for tuberculous pericarditis in the United States 2002-2014 International journal of mycobacteriology. 2019;8:347-350.
Trinh H., Irish V., Diaz M., Atiemo H. Outcomes of intradetrusor onabotulinum toxin a therapy in overactive bladder refractory to sacral neuromodulation International Neurourology Journal. 2019;23:226-233.
Menon M., Dalela D., Jamil M., Diaz M., Tallman C., Abdollah F., Sood A., Lehtola L., Miller D., Jeong W. Functional Recovery, Oncologic Outcomes and Postoperative Complications after Robot-Assisted Radical Prostatectomy: An Evidence-Based Analysis Comparing the Retzius Sparing and Standard Approaches Journal of Urology. 2018;199(5):1210-1217.
Abdollah F., Dalela D., Sood A., Sammon J., Cho R., Nocera L., Diaz M., Jeong W., Peabody J.O., Fossati N., Gandaglia G., Briganti A., Montorsi F., Menon M. Functional outcomes of clinically high-risk prostate cancer patients treated with robot-assisted radical prostatectomy: A multi-institutional analysis Prostate Cancer and Prostatic Diseases. 2017;20(4):395-400.
Dalela D., Jeong W., Prasad M.A., Sood A., Abdollah F., Diaz M., Karabon P., Sammon J., Jamil M., Baize B., Simone A., Menon M. A Pragmatic Randomized Controlled Trial Examining the Impact of the Retzius-sparing Approach on Early Urinary Continence Recovery After Robot-assisted Radical Prostatectomy European Urology. 2017;72(5):677-685.
Lieberman L., Barod R., Dalela D., Diaz-Insua M., Abaza R., Adshead J., Ahlawat R., Challacombe B., Dasgupta P., Gandaglia G., Moon D., Novara G., Porpiglia F., Mottrie A., Bhandari M., Rogers C. Use of Main Renal Artery Clamping Predominates over Minimal Clamping Techniques during Robotic Partial Nephrectomy for Complex Tumors Journal of Endourology. 2017;31(2):149-152.
Wang L., Diaz M., Stricker H., Peabody J.O., Menon M., Rogers C.G. Adding a newly trained surgeon into a high-volume robotic prostatectomy group: Are outcomes compromised? Journal of Robotic Surgery. 2017;11:69-74.
Wang L., Diaz M., Stricker H., Peabody J.O., Menon M., Rogers C.G. Erratum to: Adding a newly trained surgeon into a high-volume robotic prostatectomy group: are outcomes compromised? (Journal of Robotic Surgery, (2017), 11, 1, (69-74), 10.1007/s11701-016-0615-7) Journal of Robotic Surgery. 2017;11(1):75.
Abdollah F., Dalela D., Sood A., Sammon J., Jeong W., Beyer B., Fossati N., Rogers C., Diaz-Insua M., Peabody J., Haese A., Montorsi F., Graefen M., Briganti A., Menon M. Intermediate-term cancer control outcomes in prostate cancer patients treated with robotic-assisted laparoscopic radical prostatectomy: a multi-institutional analysis World Journal of Urology. 2016;34(10):1357-1366.
Abdollah F., Klett D., Sammon J., Dalela D., Sood A., Hsu L., Diaz M., Gupta N., Peabody J., Trinh Q., Menon M. Predicting lymph node invasion in patients treated with robot-assisted radical prostatectomy Canadian Journal of Urology. 2016;23(1):8141-8150.
Griffin M., Janosek-Albright K., Diaz-Insua M., Elshatanoufy S., Atiemo H. Quality of life outcomes in peri-urethral calcium hydroxylapatite injection International Urogynecology Journal. 2016;27(12):1879-1887.
Kryvenko O., Diaz M., Matoso A., Kates M., Cohen J., Swanson G., Epstein J. Prostate-specific Antigen Mass Density—A Measure Predicting Prostate Cancer Volume and Accounting for Overweight and Obesity-related Prostate-specific Antigen Hemodilution Urology. 2016;90:141-147.
Abdollah F., Klett D., Sood A., Sammon J., Pucheril D., Dalela D., Diaz M., Peabody J., Trinh Q., Menon M. Predicting pathological outcomes in patients undergoing robot-assisted radical prostatectomy for high-risk prostate cancer: A preoperative nomogram BJU International. 2015;116(5):703-712.
Diaz M. Performance measures of the bivariate random effects model for meta-analyses of diagnostic accuracy Computational Statistics and Data Analysis. 2015;83:82-90.
Diaz M., Peabody J.O., Kapoor V., Sammon J., Rogers C.G., Stricker H., Lane Z., Gupta N., Bhandari M., Menon M. Oncologic outcomes at 10 years following robotic radical prostatectomy European Urology. 2015;67(6):1168-1176.
Kryvenko O.N., Epstein J.I., Meier F.A., Gupta N.S., Menon M., Diaz M. Correlation of high body mass index with more advanced localized prostate cancer at radical prostatectomy is not reflected in PSA level and PSA density but is seen in PSA mass American Journal of Clinical Pathology. 2015;144(2):271-277.
Tjionas G.A., Epstein J.I., Williamson S.R., Diaz M., Menon M., Peabody J.O., Gupta N.S., Parekh D.J., Cote R.J., Jorda M., Kryvenko O.N. Average weight of seminal vesicles: An adjustment factor for radical prostatectomy specimens weighed with seminal vesicles International Journal of Surgical Pathology. 2015;23(8):617-622.
Diaz M. Editorial comment Journal of Urology. 2014;191(6):1821.
Diaz M. How far have we come in interstitial cystitis and how far to go? A methodologist's perspective Journal of Urology. 2014;191(1):11-12.
Jhaveri J., Penna F., Diaz-Insua M., Jeong W., Menon M., Peabody J. Ureteral injuries sustained during robot-assisted radical prostatectomy Journal of Endourology. 2014;28(3):318-324.
Kolon T., Herndon C., Baker L., Baskin L., Baxter C., Cheng E., Diaz M., Lee P., Seashore C., Tasian G., Barthold J. Evaluation and treatment of Cryptorchidism: AUA guideline Journal of Urology. 2014;192(2):337-345.
Martin A., Iqbal M., Sprague B., Diaz M., Rushton H., Peters C., Majd M., Pohl H. Most infants with dilating vesicoureteral reflux can be treated Nonoperatively Journal of Urology. 2014;191(5 SUPPL):1620-1627.
Sammon J.D., Pucheril D., Diaz M., Kibel A.S., Kantoff P.W., Menon M., Trinh Q.D. Contemporary nationwide patterns of self-reported prostate-specific antigen screening JAMA Internal Medicine. 2014;174(11):1839-1841.
Sood A., Ghani K., Ahlawat R., Modi P., Abaza R., Jeong W., Sammon J., Diaz M., Kher V., Menon M., Bhandari M. Application of the statistical process control method for prospective patient safety monitoring during the learning phase: Robotic kidney transplantation with regional hypothermia (ideal phase 2a-b) European Urology. 2014;66(2):371-378.
Sukumar S., Rogers C., Trinh Q., Sammon J., Sood A., Stricker H., Peabody J., Menon M., Diaz-Insua M. Oncological outcomes after robot-assisted radical prostatectomy: Long-term follow-up in 4803 patients BJU International. 2014;114(6):824-831.
Diaz M. Editorial comment Journal of Urology. 2013;190(2):501.
Donat S.M., Diaz M., Bishoff J.T., Coleman J.A., Dahm P., Derweesh I.H., Herrell S.D., Hilton S., Jonasch E., Lin D.W., Reuter V.E., Chang S.S. Follow-up for clinically localized renal neoplasms: AUA guideline Journal of Urology. 2013;190(2):407-416.
Elder J., Diaz M. Vesicoureteral reflux-the role of bladder and bowel dysfunction Nature Reviews Urology. 2013;10(11):640-648.
Kaczmarek B., Sukumar S., Kumar R., Desa N., Jost K., Diaz M., Menon M., Rogers C. Comparison of robotic and laparoscopic ultrasound probes for robotic partial nephrectomy Journal of Endourology. 2013;27(9):1137-1140.
Kaczmarek B.F., Tanagho Y.S., Hillyer S.P., Mullins J.K., Diaz M., Trinh Q.D., Bhayani S.B., Allaf M.E., Stifelman M.D., Kaouk J.H., Rogers C.G. Off-clamp robot-assisted partial nephrectomy preserves renal function: A multi-institutional propensity score analysis European Urology. 2013;64(6):988-993.
Kheterpal E., Sammon J.D., Diaz M., Bhandari A., Trinh Q.D., Pokala N., Sharma P., Menon M., Agarwal P.K. Effect of metabolic syndrome on pathologic features of prostate cancer Urologic Oncology: Seminars and Original Investigations. 2013;31(7):1054-1059.
Kovacevic L., Jurewicz M., Dabaja A., Thomas R., Diaz M., Madgy D., Lakshmanan Y. Enuretic children with obstructive sleep apnea syndrome: Should they see otolaryngology first? Journal of Pediatric Urology. 2013;9(2):145-150.
Rogers C., Sammon J., Sukumar S., Diaz M., Peabody J., Menon M. Robot assisted radical prostatectomy for elderly patients with high risk prostate cancer Urologic Oncology: Seminars and Original Investigations. 2013;31(2):193-197.
Kryvenko O., Diaz M., Meier F., Ramineni M., Menon M., Gupta N. Findings in 12-core transrectal ultrasound-guided prostate needle biopsy that predict more advanced cancer at prostatectomy: Analysis of 388 biopsy-prostatectomy pairs American Journal of Clinical Pathology. 2012;137(5):739-746.
Sammon J., Trinh Q., Sukumar S., Diaz M., Simone A., Kaul S., Menon M. Long-term follow-up of patients undergoing percutaneous suprapubic tube drainage after robot-assisted radical prostatectomy (RARP) BJU International. 2012;110(4):580-585.
Agarwal P., Sammon J., Bhandari A., Dabaja A., Diaz M., Dusik-Fenton S., Satyanarayana R., Simone A., Trinh Q., Baize B., Menon M. Safety profile of robot-assisted radical prostatectomy: A standardized report of complications in 3317 patients European Urology. 2011;59(5):684-698.
Diaz M., Norell M., Belkin J., Singh A., Reinhart W., Lass J. Cognitive profile of elders in an ophthalmic ambulatory setting British Journal of Ophthalmology. 2011;95(1):24-27.
Hoaglin D.C., Hawkins N., Jansen J.P., Scott D., Itzler R., Cappelleri J.C., Boersma C., Thompson D., Larholt K.M., Diaz M., Barrett A. Conducting indirect-treatment-comparison and network-meta-analysis studies: Report of the ISPOR task force on indirect treatment comparisons good research practices: Part 2 Value in Health. 2011;14(4):429-437.
Petros F.G., Patel M.N., Kheterpal E., Siddiqui S., Ross J., Bhandari A., Diaz M., Menon M., Rogers C.G. Robotic partial nephrectomy in the setting of prior abdominal surgery BJU International. 2011;108(3):413-419.
Koroukian S.M., Xu F., Bakaki P.M., Diaz-Insua M., Towe T.P., Owusu C. Comorbidities, functional limitations, and geriatric syndromes in relation to treatment and survival patterns among elders with colorectal cancer Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2010;65 A(3):322-329.
Menon M., Bhandari M., Gupta N., Lane Z., Peabody J.O., Rogers C.G., Sammon J., Siddiqui S., Diaz M. Biochemical recurrence following robot-assisted radical prostatectomy: Analysis of 1384 patients with a median 5-year follow-up European Urology. 2010;58(6):838-846.
Peters C., Skoog S., Arant B., Copp H., Elder J., Hudson R., Khoury A., Lorenzo A., Pohl H., Shapiro E., Snodgrass W., Diaz M. Summary of the AUA guideline on management of primary vesicoureteral reflux in children Journal of Urology. 2010;184(3):1134-1144.
Sammon J., Muhletaler F., Peabody J., Diaz-Insua M., Satyanaryana R., Menon M. Long-term functional urinary outcomes comparing single- vs double-layer urethrovesical anastomosis: Two-year follow-up of a two-group parallel randomized controlled trial Urology. 2010;76(5):1102-1107.
Skoog S., Peters C., Arant B., Copp H., Elder J., Hudson R., Khoury A., Lorenzo A., Pohl H., Shapiro E., Snodgrass W., Diaz M. Pediatric vesicoureteral reflux guidelines panel summary report: Clinical practice guidelines for screening siblings of children with vesicoureteral reflux and neonates/infants with prenatal hydronephrosis Journal of Urology. 2010;184(3):1145-1151.
Diaz M. Editorial Comment Journal of Urology. 2009;182(5):2445.
Diaz-Insua M. Methodological quality in medical evidence, quo vadis? Therapeutic Advances in Urology. 2009;1(1):51-59.
Faust W.C., Diaz M., Pohl H.G. Incidence of Post-Pyelonephritic Renal Scarring: A Meta-Analysis of the Dimercapto-Succinic Acid Literature Journal of Urology. 2009;181(1):290-298.
Szczotka-Flynn L., Ahmadian R., Diaz M. A re-evaluation of the risk of microbial keratitis from overnight contact lens wear compared with other life risks Eye and Contact Lens. 2009;35(2):69-75.
Diaz M. Editorial comment Journal of Urology. 2008;179(2):679.
Neuhauser D., Diaz M. Homeopathy or regular medicine? Cook County Hospital, Chicago, Illinois, 1882-1887: Evidence, politics, customer choice and provider perceptions at work Quality and Safety in Health Care. 2008;17(1):76-78.
Neuhauser D., Diaz M., Chalmers I. A puzzling omission in a great medical textbook edited by a pioneer of controlled trials. Journal of the Royal Society of Medicine. 2008;101(7):381-383.
Szczotka-Flynn L., Diaz M. To the editor: Risk of corneal inflammatory events with silicone hydrogel and low Dk hydrogel extended contact lens wear: A meta-analysis: Authors' response Optometry and Vision Science. 2008;85(5):364-365.
Diaz M. Editorial Comment Journal of Urology. 2007;177(2):709.
Diaz M. Editorial Comment Journal of Urology. 2007;178(4):1468.
Diaz M., Rao J.S. Non-parametric bootstrap ensembles for detection of tumor lesions Pattern Recognition Letters. 2007;28(16):2273-2283.
Diggs J.C., Xu F., Diaz M., Cooper G.S., Koroukian S.M. Failure to screen: Predictors and burden of emergency colorectal cancer resection American Journal of Managed Care. 2007;13(3):157-164.
Koroukian S., Beaird H., Duldner J., Diaz M. Analysis of injury- and violence-related fatalities in the ohio medicaid population: Identifying opportunities for prevention Journal of Trauma - Injury, Infection and Critical Care. 2007;62(4):989-995.
Koroukian S.M., Beaird H., Madigan E., Diaz M. End-of-life expenditures by Ohio Medicaid beneficiaries dying of cancer Health Care Financing Review. 2007;28(2):65-80.
Koroukian S.M., Xu F., Beaird H., Diaz M., Murray P., Rose J.H. Complexity of care needs and unstaged cancer in elders: A population-based study Cancer Detection and Prevention. 2007;31(3):199-206.
Neuhauser D., Diaz M. Quality improvement research: Are randomised trials necessary? Quality and Safety in Health Care. 2007;16(1):77-80.
Szczotka-Flynn L., Diaz M. Risk of corneal inflammatory events with silicone hydrogel and low Dk hydrogel extended contact lens wear: A meta-analysis Optometry and Vision Science. 2007;84(4):247-256.
Szczotka-Flynn L., Diaz-Insua M. To the editor: Risk of corneal inflammatory events with silicone hydrogel and low Dk hydrogel extended contact lens wear: A meta-analysis: Authors' response [2] Optometry and Vision Science. 2007;84(9):925-926.
Agarwal P., Diaz M., Elder J. Retractile testis - Is it really a normal variant? Journal of Urology. 2006;175(4):1496-1499.
Elder J.S., Diaz M., Caldamone A.A., Cendron M., Greenfield S., Hurwitz R., Kirsch A., Koyle M.A., Pope J., Shapiro E. Endoscopic therapy for vesicoureteral reflux: A meta-analysis. I. reflux resolution and urinary tract infection Journal of Urology. 2006;175(2):716-722.
Diaz M., Neuhauser D. Pasteur and parachutes: When statistical process control is better than a randomized controlled trial Quality and Safety in Health Care. 2005;14(2):140-143.
Prologo J.D., Gilkeson R.C., Diaz M., Cummings M. The effect of single-detector CT versus MDCT on clinical outcomes in patients with suspected acute pulmonary embolism and negative results on CT pulmonary angiography American Journal of Roentgenology. 2005;184(4):1231-1234.
Guwatudde D., Debanne S.M., Diaz M., King C., Whalen C.C. A re-examination of the potential impact of preventive therapy on the public health problem of tuberculosis in contemporary sub-Saharan Africa Preventive Medicine. 2004;39(5):1036-1046.
Neuhauser D., Diaz M. Daniel: Using the Bible to teach quality improvement methods Quality and Safety in Health Care. 2004;13(2):153-155.
Neuhouser D., Diaz M. Shuffle the deck, flip that coin: Randomization comes to medicine Quality and Safety in Health Care. 2004;13(4):315-316.
Prologo J.D., Gilkeson R.C., Diaz M., Asaad J. CT pulmonary angiography: A comparative analysis of the utilization patterns in emergency department and hospitalized patients between 1998 and 2003 American Journal of Roentgenology. 2004;183(4):1093-1096.
Reszko A.E., Kasumov T., David F., Thomas K.R., Jobbins K.A., Cheng J.F., Lopaschuk G.D., Dyck J.R.B., Diaz M., Des Rosiers C., Stanley W.C., Brunengraber H. Regulation of malonyl-CoA concentration and turnover in the normal heart Journal of Biological Chemistry. 2004;279(33):34298-34301.
Rimm A., Katayama A., Diaz M., Katayama K. A meta-analysis of controlled studies comparing major malformation rates in IVF and ICSI infants with naturally conceived children Journal of Assisted Reproduction and Genetics. 2004;21(12):437-443.
Diaz M., Douek D.C., Valdez H., Hill B.J., Peterson D., Sanne I., Piliero P.J., Koup R.A., Green S., Schnittman S., Lederman M.M. T cells containing T cell receptor excision circles are inversely related to HIV replication and are selectively and rapidly released into circulation with antiretroviral treatment AIDS. 2003;17(8):1145-1149.
Evans H., Horng M., Ricanati M., Diaz-Insua M., Jordan R., Schwartz J. Induction of genomic instability in TK6 human lymphoblasts exposed to <sup>137</sup>Cs γ radiation: Comparison to the induction by exposure to accelerated <sup>56</sup>Fe particles Radiation Research. 2003;159(6):737-747.
Guwatudde D., Zalwango S., Kamya M.R., Debanne S.M., Diaz M.I., Okwera A., Mugerwa R.D., King C., Whalen C.C. Burden of tuberculosis in Kampala, Uganda Bulletin of the World Health Organization. 2003;81(11):799-805.
Evans H., Horng M., Ricanati M., Diaz-Insua M., Jordan R., Schwartz J. Characteristics of genomic instability in clones of TK6 human lymphoblasts surviving exposure to <sup>56</sup>Fe ions Radiation Research. 2002;158(6):687-698.
Evans H., Horng M., Ricanati M., Diaz-Insua M., Jordan R., Schwartz J. Diverse delayed effects in human lymphoblastoid cells surviving exposure to high-LET <sup>56</sup>Fe particles or low-LET <sup>137</sup>Cs gamma radiation Radiation Research. 2001;156(3):259-271.
Díaz-Insua M., Delgado M. Modeling and simulation of the human cardiovascular system with bond graph: A basic development Computers in Cardiology. 1996:393-396.
-
Presentations
- Hospital Admissions for Mitral Stenosis in Pregnancy in the United States. A Twelve-Year Analysis. Lima N, Lima C, de Castro R, Huffman C, Diaz M, Linares S, Schauer M, Melgar M, 38th Annual Kalamazoo Community Medical and Health Sciences Virtual Research Day, Kalamazoo, Michigan, 04/2021
- Making Outbreak Investigations Real to Medical Students. Diaz M, 38th Annual Kalamazoo Community Medical and Health Sciences Virtual Research Day, Kalamazoo, Michigan, 04/2021
- Sentiment Analysis of Initiating Messages Posted Around a Brain Cancer Diagnosis in a Moderated Cancer Online Community. Sam K, Sherfield M, Diaz M, 38th Annual Kalamazoo Community Medical and Health Sciences Virtual Research Day, Kalamazoo, Michigan, 04/2021